Ghrelin in Health and Disease
Ghrelin, the endogenous ligand for the growth hormone secretagogue (GHS) receptor, is critical in the control of food intake and energy balance. The ghrelin receptors are now known to have important physiological properties as modulators of growth hormone
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Series Editor: P. Michael Conn, PhD Oregon Health & Science University Beaverton, OR, USA
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Roy G. Smith
●
Michael O. Thorner
Editors
Ghrelin in Health and Disease
Editors Roy G. Smith Department of Metabolism and Aging The Scripps Research Institute Florida Jupiter, FL, USA
Michael O. Thorner Department of Medicine University of Virginia Charlottesville, VA, USA
ISBN 978-1-61779-902-0 ISBN 978-1-61779-903-7 (eBook) DOI 10.1007/978-1-61779-903-7 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2012946723 © Springer Science+Business Media New York 2012 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is a brand of Springer Springer is part of Springer Science+Business Media (www.springer.com)
Preface
The past 5–10 years has seen an explosion of publications on the pharmacological properties of ghrelin and the implications of how this information might extrapolate to understanding ghrelin’s role in normal physiology. The pharmacological studies prompted evaluation of the potential benefits of ghrelin as a therapeutic agent in a plethora of disease states. Ghrelin treatment appears to be very well tolerated and the results are encouraging. For chronic use the short half-life and poor oral bioavailability of ghrelin will contin
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