Lymphocyte Trafficking in Health and Disease

Since the discovery of chemokines and of chemokine receptors it has become evident that expression of chemokines at the site of inflammation may regulate the composition of cellular infiltrate, thereby directing the type of immune response. Recently, the

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Series Editor Prof. Michael J. Parnham PhD Senior Scientific Advisor GSK Research Centre Zagreb Ltd. Prilaz baruna Filipovic´a 29 HR-10000 Zagreb Croatia Advisory Board G. Z. Feuerstein (Wyeth Research, Collegeville, PA, USA) M. Pairet (Boehringer Ingelheim Pharma KG, Biberach a. d. Riss, Germany) W. van Eden (Universiteit Utrecht, Utrecht, The Netherlands)

Forthcoming titles: Chemokine Biology: Basic Research and Clinical Application, Volume II: Pathophysiology of Chemokines, K. Neote, G. L. Letts, B. Moser (Editors), 2006 Endothelial Dysfunction and Inflammation, A. Graham (Editor), 2006 In Vivo Models of Inflammation, 2nd edition, C. S. Stevenson, L. A. Marshall, D. W. Morgan (Editors), 2006 The Resolution of Inflammation, A. G. Rossi, D. A. Sawatzky (Editors), 2006 (Already published titles see last page.)

Lymphocyte Trafficking in Health and Disease

Raffaele Badolato Silvano Sozzani Editors

Birkhäuser Verlag Basel · Boston · Berlin

Editors Raffaele Badolato Department of Pediatrics University of Brescia c/o Spedali Civili 25123 Brescia Italy

Silvano Sozzani Section of General Pathology and Immunology University of Brescia Vle Europa 11 25123 Brescia Italy

Library of Congress Cataloging-in-Publication Data Lymphocyte trafficking in health and disease / Raffaele Badolato, Silvano Sozzani, editors. p. ; cm. -- (Progress in inflammation research) Includes bibliographical references and index. ISBN-13: 978-3-7643-7308-5 (alk. paper) ISBN-10: 3-7643-7308-3 (alk. paper) 1. Lymphocytes. 2. Biological transports. I. Badolato, Raffaele, 1965- II. Sozzani, Silvano. III. PIR (Series) QR185.8.L9L884.2006 616.07’9--dc22 2006043595

Bibliographic information published by Die Deutsche Bibliothek Die Deutsche Bibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data is available in the internet at http://dnb.ddb.de

ISBN-10: 3-7643-7308-3 Birkhäuser Verlag, Basel – Boston – Berlin ISBN-13: 978-3-7643-7308-5 Birkhäuser Verlag, Basel – Boston – Berlin The publisher and editor can give no guarantee for the information on drug dosage and administration contained in this publication. The respective user must check its accuracy by consulting other sources of reference in each individual case. The use of registered names, trademarks etc. in this publication, even if not identified as such, does not imply that they are exempt from the relevant protective laws and regulations or free for general use. This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. For any kind of use, permission of the copyright owner must be obtained. © 2006 Birkhäuser Verlag, P.O. Box 133, CH-4010 Basel, Switzerland Part of Springer Science+Business Media Printed on acid-free paper produced from chlorine-free pulp. TCF ∞ Cover design: Markus Etterich, Basel Cover illustration: M