Lysosomes
Lysosomes are membrane-surrounded organelles which are present in all animal cells. The importance of this organelle is underlined by an increasing number of human diseases, which are associated with an impaired function of the lysosomal compartment. This
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Lysosomes Paul Saftig, Ph.D. Biochemisches Institut Christian-Albrechts-Universitat Kiel Kiel, Germany
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LYSOSOMES Medical Intelligence Unit Landes Bioscience / Eurekah.com Springer Science+Business Media, Inc. ISBN: 0-387-25562-1
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Library of Congress Cataloging-in-Publication Data Saftig, Paul. Lysosomes / Paul Saftig. p. ; cm. ~ (Medical intelligence unit) Includes bibliographical references and index. ISBN 0-387-25562-1 (alk. paper) 1. Lysosomes. I. Title. II. Series: Medical inteUigence unit (Unnumbered : 2003) [DNLM: 1. Lysosomes—enzymology. 2. Lysosomes—metabolism. 3. Biological Transport. 4. Lysosomal Storage Diseases—therapy. Q U 350 S128L 2005] QH603.L9S24 2005 571.6'55~dc22
2005013404
Dedicated to Jane and Lynn ... and all patients suffering of diseases with an impaired lysosomal function.
CONTENTS Preface 1. History and Morphology of the Lysosome Renate Lullmann-Rauch Morphology of Lysosomes History of the Lysosome Concept 2. Transport of Lysosomal Enzymes Stephan Storch and Thomas Braulke Synthesis and Modifications of Soluble Lysosomal Proteins Formation of Mannose 6-Phosphate Recognition Marker Mannose 6-Phosphate Receptors Signal Structur
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