Lysosomes Methods and Protocols
This volume provides laboratory protocols essential for studies on lysosomal biology. Chapters aim to guide researchers in their exploration of lysosomes, both under normal conditions and in pathological processes. Written in the highly successful Me
- PDF / 11,331,447 Bytes
- 314 Pages / 504.63 x 737.01 pts Page_size
- 53 Downloads / 249 Views
Karin Öllinger Hanna Appelqvist Editors
Lysosomes Methods and Protocols
Methods
in
Molecular Biology
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Lysosomes Methods and Protocols
Edited by
Karin Öllinger Experimental Pathology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
Hanna Appelqvist Department of Physics, Chemistry and Biology, Linköping University, Linköping, Sweden
Editors Karin Öllinger Experimental Pathology Department of Clinical and Experimental Medicine Linköping University Linköping, Sweden
Hanna Appelqvist Department of Physics, Chemistry and Biology Linköping University Linköping, Sweden
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-6932-6 ISBN 978-1-4939-6934-0 (eBook) DOI 10.1007/978-1-4939-6934-0 Library of Congress Control Number: 2017935483 © Springer Science+Business Media LLC 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface The endo-lysosomal system is central to the degradation and recycling of macromolecules delivered by endocytosis, phagocytosis, and autophagy [1–3]. As the major digestive compartment within cells, lysosomes harbor around 60 acidic hydrolases, responsible for the cellular digestion of most macromolecules. The lysosomal function goes far beyond the degradation activity and lysosomes are identified as important regulators of nutrient sensing, exocytosis, receptor recycling and regulation, cell death, and cholesterol homeostasis [4–7].
Data Loading...
