Mathematical Methods for Protein Structure Analysis and Design C
The papers collected in this volume reproduce contributions by leading sch- arstoaninternationalschoolandworkshopwhichwasorganizedandheldwith thegoaloftakinga snapshotofadiscipline undertumultuous growth. Indeed, the area of protein folding, docking and a
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Edited by S. Istrail, P. Pevzner, and M. Waterman Editorial Board: A. Apostolico S. Brunak M. Gelfand T. Lengauer S. Miyano G. Myers M.-F. Sagot D. Sankoff R. Shamir T. Speed M. Vingron W. Wong
Subseries of Lecture Notes in Computer Science
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Berlin Heidelberg New York Hong Kong London Milan Paris Tokyo
Concettina Guerra Sorin Istrail (Eds.)
Mathematical Methods for Protein Structure Analysis and Design C.I.M.E. Summer School Martina Franca, Italy, July 9-15, 2000 Advanced Lectures
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Series Editors Sorin Istrail, Celera Genomics, Applied Biosystems, Rockville, MD, USA Pavel Pevzner, University of California, San Diego, CA, USA Michael Waterman, University of Southern California, Los Angeles, CA, USA Volume Editors Concettina Guerra Universit`a degli Studi di Padova Dipartimento di Ingegneria dell’Informazione via Gradenigo 6a, 35131 Padova, Italy E-mail: [email protected] Sorin Istrail Celera Genomics, Applied Biosystems 45 West Gude Drive, Rockville, MD 20850, USA E-mail: [email protected]
Cataloging-in-Publication Data applied for A catalog record for this book is available from the Library of Congress. Bibliographic information published by Die Deutsche Bibliothek. Die Deutsche Bibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data is available in the Internet at .
CR Subject Classification (1998): J.3, F.2, H.2, G.2, I.3.5, I.4 ISSN 0302-9743 ISBN 3-540-40104-0 Springer-Verlag Berlin Heidelberg New York This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. Springer-Verlag Berlin Heidelberg New York a member of BertelsmannSpringer Science+Business Media GmbH http://www.springer.de © Springer-Verlag Berlin Heidelberg 2003 Printed in Germany Typesetting: Camera-ready by author, data conversion by Boller Mediendesign Printed on acid-free paper SPIN: 10927403 06/3142 543210
Preface
The papers collected in this volume reproduce contributions by leading scholars to an international school and workshop which was organized and held with the goal of taking a snapshot of a discipline under tumultuous growth. Indeed, the area of protein folding, docking and alignment is developing in response to needs for a mix of heterogeneous expertise spanning biology, chemistry, mathematics, computer science, and statistics, among others. Some of the problems encountered in this area are not only important for the scientific challenges they pose, but also for the opportunities they disclose in terms of medical and industrial exploitati
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