Molecular Mechanisms of Retina Pathology and Ways of its Correction
This book discusses the pathology of the retina, and reviews current research on the use of cell replacement therapy and short peptides to restore functional activity in retinal neurons. As the book describes, pathologies of the retina, including age-rela
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Molecular Mechanisms of Retina Pathology and Ways of its Correction
Molecular Mechanisms of Retina Pathology and Ways of its Correction
Svetlana Trofimova
Molecular Mechanisms of Retina Pathology and Ways of its Correction
Svetlana Trofimova St. Petersburg Institute of Bioregulation and Gerontology Saint Petersburg, Russia
ISBN 978-3-030-50159-4 ISBN 978-3-030-50160-0 (eBook) https://doi.org/10.1007/978-3-030-50160-0 © Springer Nature Switzerland AG 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Contents
1 Literature Review�������������������������������������������������������������������������������������� 1 1.1 Age-Related Characteristics of the Retina������������������������������������������ 1 1.1.1 Molecular Mechanisms of Age-Related Macular Degeneration �������������������������������������������������������������������������� 4 1.1.2 Molecular Mechanisms of Retinal Ischemia�������������������������� 6 1.1.3 Molecular Mechanisms of Retinitis Pigmentosa�������������������� 7 1.1.4 Conclusion������������������������������������������������������������������������������ 9 1.2 Current Trends in the Treatment of Retinal Diseases ������������������������ 9 1.3 Results of Modern Scientific Research in the Field of Cell Replacement Therapy Using Neuronal Stem Cells�������������������� 14 1.4 Biological Effects of Peptide Bioregulators���������������������������������������� 17 References���������������������������������������������������������������������������������������������������� 32 2 Results of Experimental Studies of Short Peptides (Cytogens) in Ophthalmology�����������������������������������������������������������������
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