Muscle Tissue Engineering

Skeletal muscle is a classical example of “structure determining function.” Successful strategies for clinical applications of tissue-engineered skeletal muscle must recapitulate the processes that muscle undergoes during either embryonic development or a

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Ulrich Meyer · Thomas Meyer Jörg Handschel · Hans Peter Wiesmann (Eds.)

Fundamentals of Tissue Engineering and Regenerative Medicine

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Ulrich Meyer, Prof. Dr. med. dent. Dr. med. Clinic for Maxillofacial and Plastic Facial Surgery Heinrich Heine University Düsseldorf Moorenstraße 5 40225 Düsseldorf Germany E-mail: [email protected]

Jörg Handschel, Priv.-Doz., Dr. med. dent. Dr. med. Clinic for Maxillofacial and Plastic Facial Surgery Heinrich Heine University Düsseldorf Moorenstraße 5 40225 Düsseldorf Germany E-mail: [email protected]

Thomas Meyer, Prof. Dr. med. Dr. phil. Dr. rer. nat. Department of Internal Medicine – Cardiology University Hospital Marburg Baldingerstraße 1 35033 Marburg Germany E-mail: [email protected]

Hans Peter Wiesmann, Priv.-Doz., Dr. rer. medic. Biomineralisation and Tissue Engineering Group Department of Experimental Maxillofacial Surgery University of Münster Waldeyerstraße 30 48149 Münster Germany E-mail: [email protected]

ISBN: 978-3-540-77754-0 e-ISBN: 978-3-540-77755-7 DOI: 10.1007/ 978-3-540-77755-7 Library of Congress Control Number: 2008931995 © 2009 Springer-Verlag Berlin Heidelberg This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in it current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registed names, trademarks etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: the publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Cover design: Frido Steinen-Broo, eStudio Calamar, Spain Reproduction, typesetting and production: le-tex publishing services oHG, Leipzig, Germany Printed on acid-free paper 987654321 springer.com

Preface

The man-made creation of tissues, organs, or even larger organisms was for a long time a matter of myth and dream throughout the history of medicine. It now comes into clinical reality. Tissue engineering and regenerative medicine are the terms that are nowadays used to describe the approach to generate complex tissues and organs from simpler pieces. Both are multidisciplinary, young and emerging fields in biotechnology and medicine, which are expected to change patient treatment profoundly, generating and regenerating tissues and organs instead of just repairing them. There is much promise and