MWCNT-oxazolidinone conjugates with antibacterial activity
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RESEARCH PAPER
MWCNT-oxazolidinone conjugates with antibacterial activity Bibiana Moreno-Valle & José A. Alatorre-Barajas & Yadira Gochi-Ponce & Eleazar Alcántar-Zavala & Yazmín Yorely Rivera-Lugo & Julio Montes-Ávila & Balter Trujillo-Navarrete & Gabriel Alonso-Núñez & Edgar A. Reynoso-Soto & Adrián Ochoa-Terán
Received: 7 April 2020 / Accepted: 8 October 2020 # Springer Nature B.V. 2020
Abstract In this work, two types of MWCNToxazolidinone conjugates were synthesized, by varying the quartz tube lengths in the reactor (40 cm and 60 cm), with the aim at evaluating and comparing their biological potential against nine bacterial strains. MWCNT-1 (40 cm) showed higher surface defects and lower crystallinity than MWCNT-2 (60 cm). During each step of chemical modification, the organic material incorporation onto the MWCNTs changed the surface defects, density, and thermic stability. Interestingly, due to the intrinsic antibacterial activity of the oxazolidinone compounds, oxazolidinone-conjugated nanomaterials f-
MWCNT-Sn-Oxa were active against the evaluated strains, while none of pristine MWCNT, f-MWCNT, or f-MWCNT-Sn exhibited antibacterial activity. The results point out to f-MWCNT-S1-Oxa-1 as the best antibacterial nanomaterial because it was active against several bacterial strains. Antibacterial results obtained with the f-MWCNT-Sn-Oxa-1 series demonstrate a significant effect of the oligomethylene chain (Sn) length against Staphylococcus aureus clinically isolated strain. Keywords MWCNT . Oxazolidinone . Antibacterial activity . Nanomaterials . Health effects
Bibiana Moreno-Valle and José A. Alatorre-Barajas contributed equally to this work. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11051-020-05044-w) contains supplementary material, which is available to authorized users. B. Moreno-Valle : J. A. Alatorre-Barajas : Y. Gochi-Ponce (*) : E. Alcántar-Zavala : Y. Y. Rivera-Lugo : B. Trujillo-Navarrete : E. A. Reynoso-Soto : A. Ochoa-Terán (*) Centro de Graduados en Investigación en Química, Tecnológico Nacional de México/IT de Tijuana, Tijuana, B. C., Mexico e-mail: [email protected] e-mail: [email protected] J. Montes-Ávila Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, Culiacán, Sin., Mexico G. Alonso-Núñez Centro de Nanociencias y Nanotecnología, Universidad Nacional Autónoma de México, Ensenada, B. C., Mexico
Introduction Bacterial nosocomial infections (BNIs) or hospitalacquired infections (HAIs) are those acquired and developed during a hospital stay, which were absent by the time of patient admission, and generally, those are contracted after 48 h of internment (Garner et al. 1988; Lax and Gilbert 2015; Al-Tawfiq and Tambyah 2014). HAIs represent a major problem for public health, since an increasing impact on morbidity, mortality, and quality of patients life is continuously reported. HAIs continue to be a public health challenge due to a remarked acquired resistance of clinical bacterial strains to commonly
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