Natural disesquiterpenoids: an overview of their chemical structures, pharmacological activities, and biosynthetic pathw
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Natural disesquiterpenoids: an overview of their chemical structures, pharmacological activities, and biosynthetic pathways Ying-Hong Ma . Xiu-Xiu Dou . Xin-Hui Tian
Received: 14 March 2020 / Revised: 18 May 2020 / Accepted: 5 June 2020 Ó Springer Nature B.V. 2020
Abstract Disesquiterpenoids are constructed by two sesquiterpenoid molecules, containing at least 30 carbons with various connection patterns, and numerous new skeletons have been constructed. The aim of this review is to comprehensively summarise the isolation, structural elucidation, chemical synthesis, possible biogenetic pathways, and important pharmacological activities of the natural disesquiterpenoids discovered between 2010 and 2020. Modern analytical tools and synthetic means that have led to structural revisions as well as name corrections have also been included. Here, 227 references and 470 compounds are summarized. Keywords Natural disesquiterpenoids Structures Pharmacological activity Biosynthetic pathway Abbreviations Bacillus cereus 6BIO CD CI DOX DEX
B. cereus Wnt signaling activator (GSK3b inhibitor) Circular dichroism Combined index Doxorubicin Dexamethason
Y.-H. Ma X.-X. Dou X.-H. Tian (&) Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, People’s Republic of China e-mail: [email protected]
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Phytochem Rev
Human lymphoma cells Human renal epithelial cells Human embryonic kidney cells Human acute monocytic leukemia cells Human embryonic lung cells Human immunodeficiency virus type 1 Hepatitis B virus Hepatitis C virus Helicobacter pylori IC50
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Plasmodium yoelii Phytophthora infestans PTP1B
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HBV HCV H. pylori The concentration that cause 50% reduction in cells growth The concentration that cause 50% death Intracellular lactate dehydrogenases N-monomethyl-L-arginine 3TC Mass spectrum Melting point B16 Raw264.7 BV-2 M. luteus a-Melanocyte stimulating hormone Nuclear magnetic resonance Optical rotation KB P. falciparum
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