Neural Development and Stem Cells

For the third edition of this work Dr. Rao and his fellow editors have worked diligently with the contributors to revise and expand each chapter.  Additional information about our understanding of the differentiation of pluripotent stem cells into th

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Mahendra S. Rao Melissa Carpenter Mohan C. Vemuri •

Editors

Neural Development and Stem Cells Third Edition

Editors Mahendra S. Rao NIH CRM Bethesda, MD USA

Mohan C. Vemuri Life Technologies Frederick, MD USA

Melissa Carpenter Carpenter Group Consulting, Inc. Black Diamond, WA USA

ISBN 978-1-4614-3800-7 DOI 10.1007/978-1-4614-3801-4

ISBN 978-1-4614-3801-4

(eBook)

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Preface

Neural differentiation is an early embryonic event that occurs soon after germ layer specification. In vertebrates, the early ectoderm undergoes further patterning to separate into two identifiable components: the presumptive neural ectoderm and the presumptive epidermis. Neural ectoderm tissue segregates as a clearly demarcated epithelium termed the neuropeithelium (or neuroectoderm). This neuroepithelium generates all of the major components of the central nervous system (CNS) and the peripheral nervous system (PNS), including the neural cres