New Enhanced Method for Determination of Trace Sulfamethodxazole Based on the Fluorescence Behaviors of Cyclodextrins in
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ORIGINAL ARTICLE
New Enhanced Method for Determination of Trace Sulfamethodxazole Based on the Fluorescence Behaviors of Cyclodextrins in Water Solutions Hong-ling Wang 1
&
Xue-jing Si 1 & Tun-hua Wu 2 & Ping Wang 1
Received: 27 April 2020 / Accepted: 30 June 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract The widespread occurrence of sulfonamides (SAs) in the environment water has rasied great concerns about their potential to antibiotics resistance. In this study, the fluorescence behaviors of sulfamethoxazole (SMZ) representing certain properties of the SAs mixed with three different kinds of cyclodextrins (CDs) in water solutions were investigated, respectively. The result reported that the shapes of the fluorescence peak and its position for the SMZ that were mixed with the CDs were almost the same as those of the standard SMZ, respectively. In addition, compared with the identical control sample the fluorescence of SMZ mixed with each of the CD was greatly enhanced. Therefore, a new simple, and sensitive spectrofluorimetric method for the determination of SMZ was established in water solutions. and the dynamic linear ranges varied from 0.01 to 0.7 mg/L with the detection limit of 7.1 ng/L. And the correlation coefficient was more than 99.9%. Significantly, this new method was successfully applied to direct determination of SMZ in pharmaceutical compounds. Moreover, the results showed that the SMZ could separately form the 1:1 supramolecular compound with each of the CD. Keywords Sulfamethoxazole . Fluorimetry . β-Cyclodextrin . Methyl-β-cyclodextrin . 2-hydroxypropyl-β-cyclodextrin
Introduction Antibiotic is one of the most significant discoveries and have brought a revolution in the field of medicine for human therapy. They have been widely used in the treatment of human diseases and the growth of animals and plants owing to their antibacterial and anti-inflammatory effects [1–5]. But the risks associated with antibiotics pollution is largely affecting people. Since the antibiotics are released into environment creating antibiotic pollution [2–4]. The determination of antibiotic in ground water and effluents has always been a challenge in terms of speciation, interference that might occur on the analysis due to the complexity of the matrix in which the solute is * Tun-hua Wu [email protected] * Ping Wang [email protected] 1
School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China
2
School of Information Engineering, Wenzhou Business College, Wenzhou 325035, Zhejiang, China
dissolved and the time needed to perform analysis and produce a reliable result [3–5]. Sulfonamides (SAs) are one of the most common antibiotics because of their low cost, broad antibacterial spectrum and obvious effects which are commonly used in infectious diseases therapy [6–9]. The sulfamethoxazole (SMZ) which is one kind of the SAs can control the synthesis of folic acid during cell growth and it is also widely used to treat in infections of aquatic animals
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