Pregnancy Outcome Difference between Fresh and Frozen Embryos in Women without Polycystic Ovary Syndrome: a Systematic R
- PDF / 1,929,281 Bytes
- 10 Pages / 595.276 x 790.866 pts Page_size
- 49 Downloads / 192 Views
REVIEW
Pregnancy Outcome Difference between Fresh and Frozen Embryos in Women without Polycystic Ovary Syndrome: a Systematic Review and Meta-Analysis Xuli Jin 1 & Guangbao Liu 1 & Zhi Jiao 1 & Jiali Sun 2 & Miaomiao Yan 1 & Xiaoyang Lv 1 & Haozheng Zhang 3 & Jie Chen 1 Received: 27 April 2020 / Accepted: 16 September 2020 # Society for Reproductive Investigation 2020
Abstract The purpose of this study is to identify that the advantages of frozen embryos are not evident in ovulatory women or women with non-polycystic ovary syndrome (non-PCOS) by meta-analysis. An exhaustive literature search of PubMed (MEDLINE), Embase, and Cochrane Library databases was performed until March 20, 2020 (limited to articles published in English). We included randomized clinical trials comparing the results of frozen and fresh embryo transfers. The primary outcomes were live birth rate and birth weight. The fixed effect model was used when a significant heterogeneity was observed. Otherwise, a random effect model was used. In 511 identified studies, 4 were eligible and were included in this review. There was no difference in live birth rate, singleton birth weight, clinical pregnancy, ongoing pregnancy, gestational diabetes, and gestational hypertension between frozen and fresh embryos. In frozen embryos, the relative risk of moderate or severe ovarian hyperstimulation syndrome (OHSS) was lower, the incidence rate of pre-eclampsia higher, and the standardized mean difference of twin birth weight higher than in fresh embryos. There is no significant difference between frozen embryo transfer (FET) and fresh embryo transfer in ovulatory women or women with non-PCOS. We recommend that the transfer depends on the actual situation in the patient in clinical practice, rather than the “freeze all” policy and thawing FET. Keywords Frozen embryos . Fresh embryos . Live birth rate . Birth weight
Introduction In vitro fertilization (IVF) involves hormonal stimulation of the ovary and surgical extraction and insemination of the oocytes in the laboratory. Traditionally, since it was successfully introduced in 1978, IVF has been performed by transplanting fresh embryos [1]. The embryo produced by this process is transferred to the uterus after 2–5 days of culture, and all the remaining embryos are frozen for future use. Embryos
* Jie Chen [email protected] 1
Department of Maternal and Child Health, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China
2
Department of Vascular anomalies and Interventional Radiology, Qilu Children’s Hospital of Shandong University, Jinan 250022, Shandong, China
3
Research Institute of Pediatrics, Qilu Children’s Hospital of Shandong University, Jinan 250022, China
temporarily frozen by the embryo-freezing technique are usually thawed and recovered at a specific time point in another menstrual cycle after the egg retrieval cycle and subsequently transferred into the uterine cavity. Existing systematic reviews confirmed that the risk of preterm delivery and
Data Loading...
