Paracetamol/zinc sulfate
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Lack of efficacy and off label use: case report A 35-year-old woman did not show improvement in myalgia during treatment with paracetamol and she also received off label treatment with zinc sulfate for coronavirus disease 2019 (COVID-19) [not all routes and dosages stated]. The woman, was admitted with chills, fever cough and myalgia. Five days prior, she had came in contact with her sister-in-law, who tested positive for COVID-19. In the emergency department, she showed diffuse myalgia, which was getting worse and did not improved after taking paracetamol [acetaminophen]. The blood sample was collected for culture and a nasopharyngeal swab was submitted for testing of COVID-19. Her empiric treatment was started with sodium chloride, azithromycin and ceftriaxone. Subsequently, she tested positive for COVID-19 and received oral zinc sulfate 200mg twice per day off labelly. Concomitantly, she received Ringer’s lactate at a controlled rate for rhabdomyolysis along with normal sodium chloride [saline] with close monitoring of her kidney function and oxygen saturation. Her medical condition improved on day 4 and she was discharged from hospital. Alrubaye R, et al. Severe Rhabdomyolysis in a 35-Year-old Woman with COVID-19 due to SARS-CoV-2 Infection: A Case Report. American Journal of Case Reports 21: 803502375 e926733, 2020. Available from: URL: http://doi.org/10.12659/AJCR.926733
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Reactions 26 Sep 2020 No. 1823
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