Pathogenicity Islands and the Evolution of Pathogenic Microbes Volum
It has been known for a number of years that not only pathogenicity islands but also plasmids and bacteriophages are able to carry genes whose products are involved in pathogenic processes. Accordingly, such elements and their products play an important r
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Current Topics in Microbiology and Immunology
Editors R.W. Compans, Atlanta/Georgia M. Cooper, Birmingham/Alabama Y. Ito, Kyoto H. Koprowski, Philadelphia/Pennsylvania F. Melchers, Basel M. Oldstone, La Jolla/California S. Olsnes, Oslo M. Potter, Bethesda/Maryland P.K. Vogt, La Jolla/California H. Wagner, Munich
Springer-Verlag Berlin Heidelberg GmbH
Pathogenicity Islands and the Evolution of Pathogenic Microbes Volume I
Edited by J. Hacker and J.B. Kaper
With 34 Figures and 7 Tables
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Professor Dr. JOÈRG HACKER UniversitaÈt WuÈrzburg Institut fuÈr Molekulare Infektionsbiologie RoÈntgenring 11 97070 WuÈrzburg Germany e-mail: [email protected] Professor Dr. JAMES B. KAPER University of Maryland School of Medicine Center for Vaccine Development 685 W. Baltimore Street 21201 Baltimore, MD USA e-mail: [email protected]
Cover Illustration: Distribution of chromosomal alterations among dierent pathogenic E. coli isolates. The individual chromosomes are displayed in equal length in the following order, from outwards to inwards: 536 (UPEC), IHE3034 (MENEC), 4797/97 (EHEC), E2348/69 (EPEC), C9221a (ETEC), EDL1284 (EIEC), and DPA065 (EAEC). Missing ORFs are marked by vertical lines in the individual chromosomes. The position of the deleted ORFs refers to the E. coli MG1655 chromosome (outer circle). The positions of tRNA genes frequently used as chromosomal insertion sites of horizontally acquired DNA elements are marked within the map of the E. coli strain MG1655. (Data from DOBRINDT et al. 2001b).
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Originally published by Springer-Verlag Heidelberg New York in 2002 Library of Congress Catalog Card Number 15-12910 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a speci®c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting other relevant literature. Cover Design: design & production GmbH, Heidelberg Typesetting: Scienti®c Publishing Services (P) Ltd, Madras Printed on acid-free paper
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