Pathogenicity Islands and the Evolution of Pathogenic Microbes Volum
It has been known for a number of years that not only pathogenicity islands but also plasmids and bacteriophages are able to carry genes whose products are involved in pathogenic processes. Accordingly, such elements and their products play an important r
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Current Topics in Microbiology and Immunology
Editors R.W. Compans, Atlanta/Georgia M. Cooper, Birmingham/Alabama· Y. Ito, Kyoto H. Koprowski, Philadelphia/Pennsylvania· F. Melchers, Basel M. Old stone, La Jolla/California· S. Olsnes, Oslo M. Potter, Bethesda/Maryland P.K. Vogt, La Jolla/California· H. Wagner, Munich
Springer-Verlag Berlin Heidelberg GmbH
Pathogenicity Islands and the Evolution of Pathogenic Microbes Volume I
Edited by J. Hacker and J.B. Kaper
With 34 Figures and 7 Tables
,
Springer
Professor Or. JORG HACKER Universităt Wiirzburg Institut fUr Molekulare Infektionsbiologie R6ntgenring 11 97070 Wiirzburg Germany e-mail: [email protected] Professor Or. JAMES B. KAPER University of Maryland Schoo1 of Medicine Center for Vaccine Oeve1opment 685 W. Baltimore Street 21201 Baltimore, MO USA e-mail: [email protected]
Cover Illustration: Relative poslt1on on the S. enterica serovar Typhimurium LT-2 genetic map of virulence determÎnants which are absent from E. coli K-12. The large circle represents the chromosome, the small circle the virulence plasmid, pSLT. The positions of O and 100min are indicated. The sspH] and sopE] genes are absent from strain LT-2 but are present in other serovar Typhimurium isolates. (M1AO et al. 1999; M1ROLD et al. 1999).
ISSN 0070-217X ISBN 978-3-642-07656-5 ISBN 978-3-662-09217-0 (eBook) DOI 10.1007/978-3-662-09217-0 This work is subject to copyright. AII rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permÎssion for use must always be obtained from Springer-Verlag Berlin Heidelberg GmbH. Violations are liable for prosecution under the German Copyright Law. http://www.springer.de
© Springer-Verlag Berlin Heidelberg 2002 Origina1ly published by Springer-Verlag Berlin Heidelberg New York in 2002 Softcover reprint of the hardcover 1st edition 2002 Library of Congress Catalog Card Number 15-12910 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting other relevant litera ture. Cover Design: design & production GmbH, Heidelberg Typesetting: Scientific Publishing Services (P) Ltd, Madras Production Editor: Angelique Gcouta 27/3020 - 5 4 3 2 1 O Printed on acid-free paper SPIN: 10765335
Preface
In the year 1972 the famous evolutionary biologist Theodor
Dobzhansky wrote th
