Pulmonoprotective Action of Zataria multiflora Ethanolic Extract on Cyclophosphamide-Induced Oxidative Lung Toxicity in
- PDF / 412,392 Bytes
- 8 Pages / 612.284 x 824.882 pts Page_size
- 21 Downloads / 160 Views
•1•
C
hinese Journal of Integrative Medicine
Available online at link.springer.com/journal/11655 Journal homepage: www.cjim.cn/zxyjhen/zxyjhen/ch/index.aspx E-mail: [email protected]
Original Article
Pulmonoprotective Action of Zataria multiflora Ethanolic Extract on Cyclophosphamide-Induced Oxidative Lung Toxicity in Mice Emran Habibi1,2, Mohammad Shokrzadeh1,3, Amirhossein Ahmadi1, Aroona Chabra4, Farshad Naghshvar5, Hamed Haghi-Aminjan3, and Fatemeh Salehi5 Objective:: To evaluate the protective effect of Zataria multiflora extract, an antioxidative ABSTRACT Objective Methods:: Mice were medicinal plant, against cyclophosphamide (CP)-induced oxidative lung damage in mice. Methods intraperitoneally pre-treated with various doses of Zataria multiflora extract (50, 100, 200, and 400 mg/kg) once daily for 7 consecutive days. Animals were then injected with a single 200 mg/kg intraperitoneal dose of CP 1 h after the last administration of O. vulgare. Twenty-four hours later, mice were euthanized, the lungs Results:: A single dose were immediately removed, and biochemical and histological studies were conducted. Results of CP markedly altered the levels of several biomarkers associated with oxidative stress in lung homogenates. Pretreatment with Zataria multiflora significantly inhibited the elevation of lipid peroxidation level and the depletion in glutathione content, and superoxide dismutase and catalase activities induced by CP in lung. In addition, Zataria multiflora effectively alleviated CP-induced histopathological abnormality and pulmonary Conclusions:: The results reveal that Zataria multiflora protects lung tissues from damages in mice lung tissues. Conclusions CP-induced toxicity and suggest a role for oxidative stress in the pathogenesis of lung toxicity produced by CP in mice. Because Zataria multiflora has been extensively used as an additive agent and is regarded as safe, it may be used concomitantly as a good supplement for reducing organ toxicity in patients undergoing chemotherapy, besides their consolidated ethnopharmacological uses. KEYWORDS pulmonoprotective, Zataria multiflora , cyclophosphamide, lung toxicity, oxidative stress, antioxidant activity
Lung is a target organ for toxicity caused by a variety of xenobiotics including environmental pollutants, natural toxins, and drugs.(1) Alkylating compounds, including anti-neoplastic drugs, form a large and important group of drugs that disturb the oxidant-antioxidant balance.(2) Chemotherapy with cyclophosphamide (CP), an effective immunosuppressant and antineoplastic drug, can be complicated by the development of lung fibrosis both in animals and humans.(3) Although treatment with CP results in lung injury in only about 1% of patients, it is often dose-limiting and life threatening. A single intraperitoneal injection of CP (200 mg/kg) results in lung cell injury and development of fibrosis in mice.(4) It has been reported that oxidative stress-mediated disruption of redox balance after CP exposure generates biochemical and physiological distu
Data Loading...
