140 Molecular MRI of vascular remodeling in a swine model of coronary injury using an elastin-binding contrast agent
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Meeting abstract
140 Molecular MRI of vascular remodeling in a swine model of coronary injury using an elastin-binding contrast agent Christian von Bary1, Anne Preissel2, Elmar Spuentrup3, Alexandra Keithahn4, Nikolaus Schickl1, Arno Buecker5, Simon Robinson6, Joel Lazewatsky6, Albert Schoemig1, Markus Schwaiger4, Joerg Hausleiter1 and René M Botnar*4 Address: 1Cardiology Division, Technische Universität München, München, Germany, 2Center for Preclinical Research, Technische Universität München, München, Germany, 3Diagnostic Radiology, Cologne University, Cologne, Germany, 4Nuclear Medicine, Technische Universität München, München, Germany, 5Diagnostic Radiology, University Saarland, Homburg, Germany and 6Bristol-Myers Squibb Medical Imaging, North Billerica, MA, USA * Corresponding author
from 11th Annual SCMR Scientific Sessions Los Angeles, CA, USA. 1–3 February 2008 Published: 22 October 2008 Journal of Cardiovascular Magnetic Resonance 2008, 10(Suppl 1):A41
doi:10.1186/1532-429X-10-S1-A41
Abstracts of the 11th Annual SCMR Scientific Sessions - 2008
Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1532-429X-10-S1-info.pdfThis abstract is available from: http://jcmr-online.com/content/10/S1/A41 © 2008 von Bary et al; licensee BioMed Central Ltd.
Introduction
Methods
Extracellular matrix (ECM) synthesis and degradation plays and important role in the initiation, progression and complication of atherosclerosis and in-stent restenosis but also in aneurysm formation/degradation and graft disease. Enhanced synthesis of ECM typically leads to expansive or constrictive vessel wall remodeling resulting in plaque stability but also arterial stenosis or in-stent restenosis. In contrast, advanced ECM degradation can lead to plaque instability and subsequent plaque rupture as typically observed in patients with acute coronary syndromes. In an animal study of left carotid artery injury, enhanced collagen and elastin formation was found three weeks post balloon angioplasty compared to the noninjured control vessel.
Vascular injury was induced in 6 female landrace pigs (30–35 kg) by endothelial denudation (LCX) and stent placement (LAD) or vice versa, followed by a 28 day normal diet. The RCA served as control vessel. Lasered MRlucent prototype stents (Aachen Resonance, Aachen, Germany) were used to allow artifact free imaging of the stent lumen and vessel wall. At day 28, free-breathing coronary MRA and delayed enhancement imaging of the coronary vessel walls was performed using a 1.5 T MR scanner (Achieva, Philips Medical Systems, NL) pre and after injection of 0.2 mmol/kg Gd-DTPA. Imaging parameters of the free-breathing ECG triggered and navigator (NAV) gated inversion recovery (IR) segmented gradient echo vessel wall sequence included FOV = 320 mm, matrix = 256 × 256, in-plane resolution = 1.25 × 1.25 mm, slice thickness = 3 mm, acquisition window = 50 ms, TR/TE = 4.7 ms/1.4 ms, flip angl
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