5.25 Green Tea Extracts Prevent Development of Cardiac Fibrosis in Angiotensin II-Dependent Hypertension by Blunting Oxi
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Heart 5.25 Green Tea Extracts Prevent Development of Cardiac Fibrosis in Angiotensin II-Dependent Hypertension by Blunting Oxidative Stress M. Seccia (1), A.S. Belloni (2), M. Antonello (1), A. Sandri (2), D. Guidolin (2), A.C. Pessina (1), G.P. Rossi (1) ` di Padova, Padova; (2)Dipartimento di (1)DMCS, Clinica Medica 4, Universita ` di Padova, Padova, Italy Anatomia e Fisiologia Umana, Universita Introduction. Green tea extracts (GTE) can prevent fibrosis in the skin and liver, but there are no data on the antifibrotic effect in the heart. We recently showed that GTE prevent an increase in blood pressure (BP) levels, the development of left ventricular (LV) hypertrophy and arterial remodelling in Ang II-dependent hypertension. Aim. To investigate whether GTE can prevent cardiac fibrosis by affecting the perivascular and/or interstitial compartments. Methods. Male Sprague-Dawley rats at age 13 weeks were randomly allocated to receiving one of the following treatments for 13 days: (1) vehicle (control); (2) a high dose of Ang II(700 microg/Kg day (Ang High); (3) a low dose of Ang II (350 microg/Kg day) (Ang Low); (4) a high dose of Ang II dose+GTE (6 mg/mL) (Ang High+GTE); (5) a low dose of Ang II +GTE (6 mg/mL) (Ang Low+GTE). Ang II was administered by osmotic mini-pumps, and GTE was given in the drinking water. BP was measured by telemetry (Data Sciences International, St Paul, MN). At sacrifice, left ventricular (LV) mass index was calculated as LV weight/body weight (BW), and quantitative analysis of collagen was performed on 5 microm Sirius-red-stained section using a photomicroscope Leica DM equipped with QW in Standard Leica Image software. Results. Ang High induced a persistent BP increase (P
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