Aberrant functional connectivity in resting state networks of ADHD patients revealed by independent component analysis
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RESEARCH ARTICLE
BMC Neuroscience Open Access
Aberrant functional connectivity in resting state networks of ADHD patients revealed by independent component analysis Huayu Zhang1†, Yue Zhao1,2†, Weifang Cao2,3, Dong Cui2,3, Qing Jiao2,3, Weizhao Lu2,3, Hongyu Li1* and Jianfeng Qiu2,3*
Abstract Background: ADHD is one of the most common psychiatric disorders in children and adolescents. Altered functional connectivity has been associated with ADHD symptoms. This study aimed to investigate abnormal changes in the functional connectivity of resting-state brain networks (RSNs) among adolescent patients with different subtypes of ADHD. Methods: The data were obtained from the ADHD-200 Global Competition, including fMRI data from 88 ADHD patients (56 patients of ADHD-Combined, ADHD-C and 32 patients of ADHD-Inattentive, ADHD-I) and 67 typically developing controls (TD-C). Group ICA was utilized to research aberrant brain functional connectivity within the different subtypes of ADHD. Results: In comparison with the TD-C group, the ADHD-C group showed clusters of decreased functional connectivity in the left inferior occipital gyrus (p = 0.0041) and right superior occipital gyrus (p = 0.0011) of the dorsal attention network (DAN), supplementary motor area (p = 0.0036) of the executive control network (ECN), left supramarginal gyrus (p = 0.0081) of the salience network (SN), middle temporal gyrus (p = 0.0041), and superior medial frontal gyrus (p = 0.0055) of the default mode network (DMN), while the ADHD-I group showed decreased functional connectivity in the right superior parietal gyrus (p = 0.0017) of the DAN and left middle temporal gyrus (p = 0.0105) of the DMN. In comparison with the ADHD-I group, the ADHD-C group showed decreased functional connectivity in the superior temporal gyrus (p = 0.0062) of the AN, inferior temporal gyrus (p = 0.0016) of the DAN, and the dorsolateral superior frontal gyrus (p = 0.0082) of the DMN. All the clusters surviving at p 80, and head movement less than 2.0. Subjects were enrolled if they were right-handed and their information was complete (e.g., age, Verbal IQ, or Performance IQ). Finally, fMRI data from a total of 155 volunteers aged between 7 and 17 years were collected, including 67 typically developing controls (TD-C), 56
ADHD-C patients, and 32 ADHD-I patients (the number of ADHD-HI patients was too small to be studied). IBM SPSS software (Armonk, NY, v. 22.0) was used for statistical analysis. One-way analysis of variance was performed with age, ADHD index, verbal IQ, performance IQ, and Full IQ, and the Chi squared test was used to evaluate the differences in gender among the three groups. A p value
Zhang et al. BMC Neurosci
(2020) 21:39
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Fig. 2 Six components obtained from all subjects and the corresponding resting state networks. Color bar indicates the t-value. AN: auditory network. DAN: dorsal attention network. DMN: default mode network. ECN: executive control network. SMN: sensorimotor network. SN: salience network
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