Acute Effect of Aloe vera Gel Extract on Experimental Models of Pain
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Acute Effect of Aloe vera Gel Extract on Experimental Models of Pain Naveen Rathor,1 Ashish K. Mehta,2 Amit K. Sharma,1 Pramod K. Mediratta,1,3 and Krishna K. Sharma1
Abstract—The present study was performed to explore the effect of aqueous extract of Aloe vera on behavioural parameters of pain. Pain assessment was performed by the tail-flick and formalin tests. A. vera (100 mg/kg, per oral (p.o.)) produced an insignificant decrease in the pain response in the tail-flick and formalin tests. Moreover, A. vera (200 and 400 mg/kg, p.o.) did not have significant effect on the tail-flick test. However, A. vera (200 and 400 mg/kg, p.o.) significantly decreased the second phase of the formalin-induced pain. Thus, these findings suggest that A. vera exerts its effect by a peripheral mechanism of action rather than central. KEY WORDS: Aloe vera; tail-flick test; formalin test; inflammatory pain.
INTRODUCTION Aloe vera Linn. (Aloe barbadensis Miller) belongs to Liliaceae family and has been used as an ingredient in many cosmetic products [1]. It has been demonstrated that aloe gel decreased blood glucose levels and improved lipid profile status after oral administration in streptozotocin-induced diabetic rats [2, 3]. It has also been known to enhance wound healing in hairless mice, in addition to its antibacterial and antifungal properties [4, 5]. It has gained high importance due to its role in atopic dermatitis and various immunologically induced skin disorders [6]. In an earlier study, A. vera extract was observed to inhibit oxidation of arachidonic acid in vitro [7]. In burn wounds treated with A. vera, the PGF2α levels were decreased while PGE2 levels were increased as compared to the control group [8]. A. vera has also showed potential in the treatment of the inflammatory response of the gastric mucosa due to Helicobacter pylori infection [9]. Thus, though some evidence of the 1
Department of Pharmacology, University College of Medical Sciences (University of Delhi), Delhi 110095, India 2 Department of Physiology, University College of Medical Sciences, Delhi 110095, India 3 To whom correspondence should be addressed at Department of Pharmacology, University College of Medical Sciences (University of Delhi), Delhi 110095, India. E-mail: [email protected]
1900 0360-3997/12/0600-1900/0
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2012 Springer Science+Business Media, LLC
antinociceptive activity of A. vera is present in the existing literature, exact mechanism has not been reported. The present study was, therefore, undertaken to investigate the antinociceptive effect of aqueous extract of A. vera leaf gel on animal models of pain.
MATERIALS AND METHODS Plant Material A. vera extract was obtained from M/s Indo World Trading Corporation, New Delhi (Batch no. IWTC/711/ 9432). As per the literature provided by the manufacturer, the gel obtained from A. vera leaf was mixed with double distilled water in the ratio 1:1, mechanically shaken at room temperature and concentrated in the evaporator, followed by lyophilisation to obtain a brown powder with characteristic odour
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