Analysis of procalcitonin and CRP concentrations in serum of patients with chronic spontaneous urticaria
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Inflammation Research
ORIGINAL RESEARCH PAPER
Analysis of procalcitonin and CRP concentrations in serum of patients with chronic spontaneous urticaria A. Kasperska-Zajac • A. Grzanka • E. Machura • B. Mazur M. Misiolek • E. Czecior • J. Kasperski • J. Jochem
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Received: 23 October 2012 / Revised: 21 November 2012 / Accepted: 26 November 2012 / Published online: 4 December 2012 Ó The Author(s) 2012. This article is published with open access at Springerlink.com
Abstract Background Our previous findings showed the importance of analysing the peripheral markers of acute phase response (APR) activation, C-reactive protein (CRP) and IL-6 in the context of urticaria activity and severity. However, these biomarkers do not reliably differentiate between APR to infectious and the disease severity.
Responsible Editor: Andras Falus. A. Kasperska-Zajac (&) Chair and Clinical Department of Internal Diseases, Allergology and Clinical Immunology, Medical University of Silesia, ul. Ceglana 35, 40-952 Katowice, Poland e-mail: [email protected] A. Grzanka Department of Internal Diseases, Dermatology and Allergology, Medical University of Silesia in Katowice, Katowice, Poland E. Machura Chair and Department of Pediatric in Zabrze, Medical University of Silesia, Zabrze, Poland B. Mazur Department of Microbiology and Immunology, Medical University of Silesia, ul. Jordana 19, 41-808 Zabrze, Poland M. Misiolek E. Czecior Chair and Clinical Department of Otolaryngology in Zabrze, Medical University of Silesia, Katowice, Poland J. Kasperski Department of Prosthetic Dentistry in Bytom, Medical University of Silesia, Katowice, Poland J. Jochem Department of Basic Medical Sciences, Medical University of Silesia, ul. Piekarska 18, 41-902 Bytom, Poland
Aim In order to investigate a possible association between the immune-inflammatory activation markers CRP and procalcitonin (PCT). Methods Serum PCT and CRP concentrations were measured in patients with CU of varying severity as well as in healthy subjects. Results Serum PCT and CRP concentrations were significantly increased in more severe CU patients when compared to healthy controls and mild CU, and within the CU population there was a significant correlation between concentrations of PCT and CRP. Serum PCT concentrations remained within normal ranges in most CU patients and were only slightly elevated in some severe CU cases. Conclusions PCT serum concentration may be only slightly elevated in some cases of severe CU. Upregulation of PCT synthesis accompanied by parallel changes in CRP concentration reflects a low-grade systemic inflammatory response in CU. PCT should be considered as a better marker than CRP to distinguish between APR to infection and an active non-specific urticarial inflammation. Keywords Procalcitonin Chronic urticaria Acute phase response C-reactive protein
Introduction Spontaneous chronic urticaria (CU) can be identified as a mast cell- and basophil-dependent inflammatory disorder of the skin accompanied by acute phase response (APR) [1]. This process i
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