Anti-inflammatory effects of a topical emulsion containing Helianthus annuus oil, glycerin, and vitamin B3 in mice
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Journal of Pharmaceutical Investigation https://doi.org/10.1007/s40005-020-00508-6
ORIGINAL ARTICLE
Anti‑inflammatory effects of a topical emulsion containing Helianthus annuus oil, glycerin, and vitamin B3 in mice Leandro Mendes Freitas1 · Flavia Tasmin Techera Antunes3 · Eliane Sempe Obach1 · Aurea Pandolfo Correa2 · Elenir Wiiland2 · Liciane de Mello Feliciano2 · Adriana Reinicke2 · Gabriela Jouglard Vasquez Amado3 · Ivana Grivicich3 · Maria Fernanda Pessano Fialho4 · Isadora Nunes Rebelo2 · Alessandra Hubner de Souza1,2,3 Received: 9 June 2020 / Accepted: 16 November 2020 © The Korean Society of Pharmaceutical Sciences and Technology 2020
Abstract Purpose The pharmaceutical industry has been searching for drugs that aim at the prevention, the protection, and the recovery of the skin. Thus, the aim of this study was to evaluate the anti-inflammatory and anti-edematogenic activities of a topical emulsion containing Helianthus annuus oil (5%), glycerin (30%), and vitamin B3 (5%). Methods The aim was verified through chronic inflammatory responses and edema that were induced by irritant croton oil in the ears of mice, followed by histological and leukocyte infiltration. The study also affirmed the stability and the cytotoxicity of the emulsion. Results A stable, homogeneous, shiny, slightly-white, and gelatinous emulsion was obtained. The cytotoxicity evaluation allowed for the verification that only in high concentrations were unsatisfactory results presented. The treatment was effective in reversing the inflammatory parameters that were induced by croton oil, such as edema, neutrophil migration, and cell hyperproliferation. Conclusion The developed emulsion containing sunflower oil, glycerin, and vitamin B3 had parameters of stability and presented anti-inflammatory activities. The researchers’ findings suggest that the topical use of this formulation is a new and novel strategy for the treatment of inflammatory conditions of the skin. Keywords Anti-inflammatory · Glycerin · Vitamin B3 · Emulsion · Sunflower oil · Ear edema * Alessandra Hubner de Souza [email protected]
Maria Fernanda Pessano Fialho [email protected]
Leandro Mendes Freitas [email protected]
Isadora Nunes Rebelo [email protected]
Flavia Tasmin Techera Antunes [email protected]
1
Graduation Program in Applied Genetics and Toxicology, Lutheran University of Brazil, Avenida Farroupilha 8001, District São José, Canoas, Rio Grande Do Sul 92425‑900, Brazil
Aurea Pandolfo Correa [email protected]
2
Department of Pharmacy, Lutheran University of Brazil, Avenida Farroupilha 8001, Canoas 92425‑900, Brazil
Elenir Wiiland [email protected]
3
Graduate Program in Cellular and Molecular Biology Applied To Health, Lutheran University of Brazil, Avenida Farroupilha 8001, Canoas 92425‑900, Brazil
4
Graduate Program in Biological Sciences, Biochemical Toxicology, Center of Natural and Exact Sciences, Federal University of Santa Maria, Rua Tuiuti, 2223/203, Santa Maria, B
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