Antibiotic prophylaxis for urodynamic testing in women: a systematic review
- PDF / 775,011 Bytes
- 12 Pages / 595.276 x 790.866 pts Page_size
- 67 Downloads / 240 Views
REVIEW ARTICLE
Antibiotic prophylaxis for urodynamic testing in women: a systematic review Anouk Benseler 1 & Breffini Anglim 2 & Zi Ying Zhao 3 & Chris Walsh 4 & Colleen D. McDermott 2 Received: 1 June 2020 / Accepted: 13 August 2020 # The International Urogynecological Association 2020
Abstract Introduction and hypothesis Urinary tract infection is the most common complication after urodynamic studies (UDS). Practice guidelines recommend against antibiotic prophylaxis based on an outdated review of the literature, which advised on the premise of “a lack of good quality studies” and based on an assumed low incidence not consistently supported by the literature. Objectives This systematic review aims to update the assessment of the efficacy of antibiotic prophylaxis compared with placebo or no treatment for prevention of urinary tract infection in females over the age of 18 years undergoing UDS. Methods MEDLINE, EMBASE, COCHRANE, DISSERTATIONS, conference proceedings and clinical trial registries were searched for relevant randomized controlled trials. Two authors independently screened and selected articles, assessed these for quality according to Cochrane guidelines and extracted their data. Results A total of 2633 records were screened, identifying three relevant randomized controlled trials. The one study that was critically appraised as being the least likely biased showed a statistically significant effect of antibiotic prophylaxis in reducing bacteriuria post UDS in female patients. The other two studies included in the review did not. None of the studies included were powered to show a significant change in the incidence of urinary tract infection following UDS in female patients receiving antibiotic prophylaxis versus no prophylaxis. Conclusions Similar to the 2012 Cochrane review on this subject, this systematic review demonstrated that antibiotic prophylaxis may decrease bacteriuria in women post UDS; however, further research is required to assess its effect on urinary tract infections in this context. Keywords Antibiotic prophylaxis . Systematic review . Urinary tract infection . Urodynamics . Women
Introduction A urodynamic study (UDS) is a widely used diagnostic tool for the evaluation of female lower urinary tract dysfunction [1]. Urinary tract infection (UTI) is the most common complication associated with UDS, as the required urethral
* Colleen D. McDermott [email protected] 1
Department of Obstetrics and Gynecology, University of Toronto, Toronto, Canada
2
Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, 8-815, 700 University Ave., Toronto, Ontario, Canada
3
Faculty of Medicine, University of Toronto, Toronto, Canada
4
Sidney Liswood Library, Sinai Health System, Toronto, Canada
catheterization may cause tissue damage and the introduction of external pathogens [2]. Incidence estimates of UTI following UDS vary widely; however, the literature reports rates as high as 28% [3].
Data Loading...
