Assesment of cardiac volumes in children with congenital heart disease using a 3D dual cardiac phase technique and a new
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BioMed Central
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Assesment of cardiac volumes in children with congenital heart disease using a 3D dual cardiac phase technique and a new segmentation tool Tarique Hussain*1, Hannah Bellsham-Revell1, Sergio Uribe2, Aaron Bell1, Reza Razavi1, Phillip Beerbaum1, Isra Valverde1, Tobias Schaeffter1 and Gerald Greil1 Address: 1King's College London, London, UK and 2Pontificia Universidad Catolica de Chile, Santiago, Chile * Corresponding author
from 13th Annual SCMR Scientific Sessions Phoenix, AZ, USA. 21-24 January 2010 Published: 21 January 2010 Journal of Cardiovascular Magnetic Resonance 2010, 12(Suppl 1):P2
doi:10.1186/1532-429X-12-S1-P2
Abstracts of the 13th Annual SCMR Scientific Sessions - 2010
Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/files/pdf/1532-429X-11-S1-infoThis abstract is available from: http://jcmr-online.com/content/12/S1/P2 © 2010 Hussain et al; licensee BioMed Central Ltd.
Introduction For children with complex congenital heart disease (CHD), the decision regarding univentricular or biventricular surgical repair may depend on accurate ventricular volume assessment. We have previously shown that threedimensional (3d) whole-heart imaging acquired during end-systole and end-diastole (dual-phase) during one free-breathing MRI examination, when combined with semi-automatic analysis, may be more reproducible in calculating ventricular volumes than standard techniques (Uribe et al, 2008). We describe here, for the first time, use of 3d dual-phase imaging in children with complex CHD.
Purpose To show 3d dual-phase imaging is feasible in children with complex CHD despite high heart rates.
Methods The dual-phase sequence was used alongside standard 2d multi-slice cine in ten children with complex CHD (table 1). Analysis required a new semi-automatic segmentation tool which incorporates multiplanar reformatting and volume rendering to identify ventricular boundaries (ViewForum, Philips Healthcare, Figure 1). Two observers independently assessed end-diastolic and end-systolic ventricular volumes using both standard 2d cine with manual segmentation and new 3d dual-phase with semi-
automatic segmentation. If applicable, stroke volumes obtained were compared to phase contrast results. BlandAltman was used to assess agreement and Pearson's coefficient for correlation.
Results The mean age was 3 yrs (range 3 months-9 yrs) and heart rate range was 58-139 bpm. Volumetric analysis was feasible in all cases. Inter- and Intra-observer variability was similar for both methods. For 2d cine, acquired resolution was 1.8 mm × 1.8 mm; slice thickness 5 to 6 mm & temporal resolution 30 ms (20-40 phases). For 3d dual-phase, acquired resolution was 1.3 mm isotropic & temporal resolution 60 ms (2 phases). Bland-Altman (Figure 2A (systole), 2B (diastole)) showed excellent agreement between standard 2d cine and 3d dual-phase analyses (also, correlation 0.96(systole) and 0.93(diastole)). Sim
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