Association of serum concentrations of perfluoroalkyl compounds with poor growth and failure to weight gain in 2-year-ol
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POSTER PRESENTATION
Open Access
Association of serum concentrations of perfluoroalkyl compounds with poor growth and failure to weight gain in 2-year-old children Young Ah Lee1*, Jin Hee Kim2,3, Hwa Young Kim1, Haewoon Jung1, Jieun Lee1, Juyoung Yoon1, Sanghyuk Bae2,4, Yun-Chul Hong2,3,4, Choong Ho Shin1, Sei Won Yang1 From 8th APPES Biennial Scientific Meeting Darwin, Australia. 29 October – 1 November 2014 Backgrounds Potential health concerns of perfluoroalkyl compounds (PFCs) have been raised. Objectives We investigated the relationship between exposure to PFCs and growth parameters in Korean 2-year-old children. Methods Three hundred sixty children (189 boys, 1.9 to 2.2 years) born as appropriate gestational age infants were enrolled. Height and weight at visit, birth weight, midparental height (MPH) and bone age (BA) were evaluated. Results Among fifteen PFCs analyzed, perfluorohexane sulfonic acid (PFHxS), and perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) were detected in >90% of the serum samples. The number of chemicals above median concentrations among these 5 PFCs were graded on a scale of 0 to 5, and classified into exposure (0) (n = 97), exposure (1-2) (n = 88), and exposure (≥3) groups. After adjusting for sex, birth weight, MPH, and BA, log-transformed PFHxS, PFOS, PFOA, and PFDA were associated with a 1.60, 1.35, 1.57, 1.29 cm decrease in height (all P < 0.005). Logtransformed PFOS, PFOA, PFNA, and PFDA were negatively related to weight gain (all P < 0.05). Change in weight Z-scores decreased progressively from exposure
(0), to exposure (1-2), and to exposure (≥3) (mean +0.43 vs. +0.29 vs. +0.10, P = 0.012).
Conclusions Increased concentrations of PFOS, PFOA, PFNA, and PFDA were associated with short stature and failure to weight gain in 2-year-old children. The more PFCs detected above median concentrations, the shorter and the poorer weight gain. Further prospective studies are needed to clarify causal relationship. Authors’ details 1 Department of Pediatrics, Seoul National University Children’s Hospital, Seoul, Korea. 2Environmental Health Center, Seoul National University College of Medicine, Seoul, Korea. 3Department of Environmental Health, Graduate School of Public Health, Seoul Nati, Korea. 4Institute of Environmental Medicine, Seoul National University Medical Research, Seoul, Korea. Published: 28 April 2015
doi:10.1186/1687-9856-2015-S1-P31 Cite this article as: Ah Lee et al.: Association of serum concentrations of perfluoroalkyl compounds with poor growth and failure to weight gain in 2-year-old children. International Journal of Pediatric Endocrinology 2015 2015(Suppl 1):P31.
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Department of Pediatrics, Seoul National University Children’s Hospital, Seoul, Korea Full list of author information is available at the end of the article © 2015 Ah Lee et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://cre
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