Associations of whole blood polyunsaturated fatty acids and insulin resistance among European children and adolescents
- PDF / 251,851 Bytes
- 5 Pages / 595.276 x 790.866 pts Page_size
- 36 Downloads / 195 Views
SHORT COMMUNICATION
Associations of whole blood polyunsaturated fatty acids and insulin resistance among European children and adolescents Sarah Marth 1 & Claudia Börnhorst 1 & Kirsten Mehlig 2 & Paola Russo 3 & Luis A. Moreno 4 & Stefaan De Henauw 5 & Toomas Veidebaum 6 & Dénes Molnár 7 & Michael Tornaritis 8 & Patrizia Risé 9 & Maike Wolters 1 & on behalf of the IDEFICS and I.Family consortia Received: 14 October 2019 / Revised: 10 March 2020 / Accepted: 16 March 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract This study aims to examine the association of whole blood n-3 and n-6 polyunsaturated fatty acids (PUFA) with insulin resistance (IR) in children. Whole blood fatty acids were measured in 705 children aged 2–9 years of the European IDEFICS/I.Family cohort using gas chromatography in units of weight percentage of all detected fatty acids (%wt/wt). IR was determined by the Homeostasis Model Assessment for IR (HOMA). Mixed effect models were used to assess the associations between selected baseline PUFA and HOMA z-scores at baseline and after 2- and 6-year follow-ups using models with basic and additional confounder adjustment as well as stratified by sex and weight status. In the basic model, α-linolenic (β = 1.46 SD/%wt/wt, p = 0.006) and eicosapentaenoic acid (β = 1.17 SD/%wt/wt, p = 0.001) were positively associated with baseline HOMA z-score. In the stratified analyses, α-linolenic acid was positively associated with HOMA z-score in girls only (β = 1.98 SD/%wt/wt, p = Sarah Marth and Claudia Börnhorst shared first authorship. Communicated by Gregorio Paolo Milani Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00431-020-03636-1) contains supplementary material, which is available to authorized users. * Maike Wolters [email protected]
Patrizia Risé [email protected]
Sarah Marth [email protected]
1
Leibniz Institute for Prevention Research and Epidemiology – BIPS, Achterstr. 30, 28359 Bremen, Germany
Claudia Börnhorst [email protected]
2
Sahlgrenska School of Public Health and Community Medicine, University of Gothenburg, Gothenburg, Sweden
Kirsten Mehlig [email protected]
3
Institute of Food Sciences, National Research Council, Avellino, Italy
Paola Russo [email protected]
4
GENUD (Growth, Exercise, Nutrition and Development) Research Group, Instituto Agroalimentario de Aragón (IA2), Instituto de Investigación Sanitaria Aragón (IIS Aragón), Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERObn), University of Zaragoza, Zaragoza, Spain
Stefaan De Henauw [email protected]
5
Department of Public Health, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
Toomas Veidebaum [email protected]
6
National Institute for Health Development, Tallinn, Estonia
7
Department of Pediatrics, Medical School, University of Pécs, Pécs, Hungary
8
Research and Education Institute of Child Health, Strovolos, Cyprus
9
DISFARM, Depar
Data Loading...
