Audiovestibular clinician experiences and opinions about cisplatin vestibulotoxicity
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OTOLOGY
Audiovestibular clinician experiences and opinions about cisplatin vestibulotoxicity Pattarawadee Prayuenyong1,2,3,5 · Anand V. Kasbekar1,2,3 · Deborah A. Hall1,2,3,4 · David M. Baguley1,2,3 Received: 10 January 2020 / Accepted: 1 May 2020 © The Author(s) 2020
Abstract Purpose Vestibulotoxicity associated with cisplatin chemotherapy is known to exist, but the extent, severity, and impact is unclear from the literature. This study explored knowledge, experiences, and opinions of audiovestibular professionals about cisplatin vestibulotoxicity. Methods An online survey was disseminated to clinicians working in the audiovestibular field. Results Ninety-three respondents participated in the survey. Most professionals were aware of potential vestibulotoxicity associated with cisplatin chemotherapy. Thirty-three percent of the respondents reported that they had seen patients with cisplatin vestibulotoxicity. Forty percent of them were confident in making the diagnosis and in managing the patient in this situation. The prevalence and impact of vestibulotoxicity including practicality of the assessment should be considered when designing an effective vestibulotoxicity screening protocol. Conclusion This study provides a better understanding of cisplatin vestibulotoxicity from the perspectives of audiovestibular clinicians, which will underpin appropriate detection and management of the condition. Keywords Audiovestibular · Cisplatin · Vestibular · Vestibulotoxicity
Introduction Cisplatin is a highly effective chemotherapeutic agent against a variety of life-threatening cancers, but its ototoxic effect is considerably problematic and limits usage and dosage [1]. Ototoxicity refers to drug-related damage affecting the inner ear structures, which can be characterized by cochlear dysfunction or vestibular dysfunction or both [2]. A variable degree of irreversible hearing loss as a result of cisplatin treatment is well documented with a reported * Pattarawadee Prayuenyong [email protected] 1
Hearing Sciences, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, UK
2
NIHR Nottingham Biomedical Research Centre, Ropewalk House, 113 The Ropewalk, Nottingham, UK
3
Nottingham University Hospitals NHS Trust, Nottingham, UK
4
University of Nottingham Malaysia, Semenyih, Malaysia
5
Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand
prevalence of 50–90%, depending on patient demographics, drug dosage, and differences in tools and grading system [3–5]. Given that the auditory and vestibular organs of the inner ear share vascular, neural, and fluid supplies [6, 7], an ototoxic drug may affect both compartments. The vestibular part of the inner ear plays a vital role in the complex and dynamic human balance system, together with interactions of visual, somatosensory, and central nervous systems [8]. Balance problems such as dizziness and unsteadiness can cause significant negativ
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