Cisplatin
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First report of Marchiafava-Bignami disease: case report A 51-year-old non-alcoholic woman with basoloid carcinoma of the anus developed Marchiafava-Bignami disease (MBD) following treatment with cisplatin [route, dosage and duration of treatment to reaction onset not stated]. The woman presented with confusion, agitation, visual hallucinations, apraxia and aphasia after receiving cisplatin and fluorouracil. An MRI of the brain revealed MBD, characterised by a new hypertense signal in the splenium of the corpus callosum. Other aetiologies causing similar MRI findings were excluded. Cisplatin and fluorouracil were discontinued. The woman received vitamin supplementation, and returned to baseline after a few weeks. A repeat MRI 9 weeks later revealed complete resolution of the abnormality. Author comment: "We report the first case to develop reversible lesion in the splenium of the corpus callosum suspected to be triggered by Cisplatin." Zhu L, et al. Marchiafava-Bignami Disease in a Non-Alcoholic Female Receiving Cisplatin. 63rd Annual Meeting of the American Academy of Neurology : abstr. P03.281, 9 Apr 2011. Available from: URL: http://www.aan.com 803053795 USA
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Editorial comment: A search of AdisBase, Medline, Embase and the WHO ADR database revealed no previous reports of Marchiafava-Bignami disease associated with cisplatin.
0114-9954/10/1350-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Reactions 7 May 2011 No. 1350
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