Biocompatibility and anticancer activity of L-phenyl alanine-coated iron oxide magnetic nanoparticles as potential chrys
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Elham Javani and Marziyeh Salehiabar Zanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, Zanjan 009824, Iran
Hamidreza Kheiri Manjili Zanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan 009824, Iran
Soodabeh Davaran Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 009841, Iran
Hossein Danafara) Department of Pharmaceutical Biomaterials, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan 009824, Iran; and Zanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, Zanjan 009824, Iran (Received 29 December 2017; accepted 1 May 2018)
In this project, we described the production of chrysin-loaded L-phenyl alanine (Phe)-coated iron oxide magnetic nanoparticles (chrysin@Phe@IOMNs). chrysin@Phe@IOMNs were characterized by X-ray diffraction, thermogravimetric analysis, fourier transform infrared spectroscopy, vibrating sample magnetometer, and transmission electron microscopy techniques. Next, hemocompatibility and biocompatibility of Phe-coated IOMNs were determined by hemolysis and MTT assays on HFF-2 and HEK-293 cell lines, respectively. Finally, the anticancer activity of chrysin@Phe@IOMNs was examined on MCF-7 cell line. The outcomes direct that as-prepared nanocarriers are nontoxic and biocompatible and also chrysin@Phe@IOMNs are appropriate for chrysin delivery and other hydrophobic therapeutic agents.
I. INTRODUCTION
In the past, nanotechnology has appeared as one of the very vital fields of pharmaceutical science and more specifically in drug delivery field.1 In this field, several studies were carried out and it was found that having noble carrier, most of the currently available drugs have limited potential because they are very toxic, insoluble in water, possess side effects, or highly expensive, and thus beyond the reach of the majority. At this time, over than 100 natural therapeutic molecules are in clinical progress, mostly for anticancer activities.2 Flavonoids are a number of ordinary anticancer agents, while the lack of water solubility limited their medical and pharmaceutical claims.3,4 Chrysin (5,7-dihydroxyflavone) is a natural flavonoid which is extracted from herbs and has been testified to have several important biological properties a)
Address all correspondence to this author. e-mail: [email protected] DOI: 10.1557/jmr.2018.148
on the procedures of chemical defense, nitrogen fixation, inflammation, oxidation, and anti-inflammatory and antioxidant effects.5,6 But, the lacking in solubility reduces its bioavailability and medical and pharmaceutical claims.7 Chrysin also exhibits chemopreventive activity through the induction of apoptosis in a various series of cancers cells.8 Forasmuch as free drugs may not diffuse specifically, nanocarriers can enter into the tumor area through the lack in vessels by the enhanced permeability and retention effect.9 Among the nanosystems that are used for drug delivery and especially cancer therapy,10–13 ir
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