BRD4 and PIN1 gene polymorphisms are associated with high pulse pressure risk in a southeastern Chinese population
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RESEARCH ARTICLE
Open Access
BRD4 and PIN1 gene polymorphisms are associated with high pulse pressure risk in a southeastern Chinese population Jin‑jia Qiu1†, Rui‑zhi Yang1†, Yi‑jie Tang2, Ying‑yi Lin1, Hao‑jie Xu1, Na Zhang1, Min Liang1, Hong‑da Cai1, Kai Zeng1* and Xiao‑dan Wu2*
Abstract Background: BRD4 and PIN1 have been described to be involved in inflammation and vascular endothelial cell dys‑ function, which in turn may increase pulse pressure. Hypothesis: Genetic mutations within the BRD4 and PIN1 genes could affect the risk of high pulse pressure. Methods: A total of four single nucleotide polymorphisms (SNPs) (BRD4: rs4808278; PIN1: rs2233678, rs2287838, and rs2233682) were genotyped in a cohort of 666 hypertensive patients and 232 normotensive controls with Chinese Han origin. Generalized multifactor dimensionality reduction (GMDR) was used to screen the best interaction combi‑ nation among the four SNPs within the BRD4 and PIN1 genes and diabetes. Logistic regression analysis was performed to calculate the odds ratio (ORs) (95% confidence interval (CI)) for the association between the four SNPs. Results: Adjusted for age, weight, waist circumference, drinking, smoking, hypertension, and diabetes, high pulse pressure risk was significantly higher for carriers with the rs4808278-TT genotype in BRD4 than those with wild geno‑ types (OR: 0.400, 95% CI: 0.217–0.737, P*
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