Carboplatin
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Anaphylaxis in an infant: case report Following diagnosis of optic nerve glioma, a 1-year-old girl was scheduled to receive 1 year of chemotherapy comprising vincristine and IV carboplatin 300 mg/m2 given as a 1-hour infusion twice every 4 weeks. In cycle 7, she experienced an anaphylactic reaction with pruritus, maculopapular rash, diaphoresis, respiratory distress, anxiety and elevated HR. She was immediately given epinephrine [adrenaline], hydrocortisone and diphenhydramine which alleviated her symptoms. A skin test for carboplatin was positive. One week after her first hypersensitivity response, a rechallenge with carboplatin was performed and her anaphylactic symptoms recurred. Based on the need to continue carboplatin chemotherapy, a desensitisation protocol was undertaken consisting of a continuous and progressive infusion of diluted carboplatin. The procedure was performed prior to each cycle and she was able to complete her scheduled chemotherapy. Author comment: "According to the algorithm of Naranjo et al, the adverse drug reaction would be classified as definitely associated to [carboplatin] with a score of 11." Montiel Herrera JM, et al. Carboplatin hypersensitivity and desensitization in an infant. Therapeutic Drug Monitoring 32: 525-528, No. 4, Aug 2010. Available 803038306 from: URL: http://dx.doi.org/10.1097/ftd.0b013e3181dbdf8e - Mexico
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Editorial comment: Some details of this case were previously summarised in an abstract [see Reactions 1285 p10-11; 803004707].
0114-9954/10/1319-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Reactions 18 Sep 2010 No. 1319
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