Cardiac fibrosis and microvascular damage detected by cardiac mr are a hallmark of systemic sclerosis heart involvement
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BioMed Central
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Cardiac fibrosis and microvascular damage detected by cardiac mr are a hallmark of systemic sclerosis heart involvement Martha Morelos Address: Instituto Nacional de Ciencias Médicas y Nutrición, mexico, Mexico from 13th Annual SCMR Scientific Sessions Phoenix, AZ, USA. 21-24 January 2010 Published: 21 January 2010 Journal of Cardiovascular Magnetic Resonance 2010, 12(Suppl 1):O54
doi:10.1186/1532-429X-12-S1-O54
Abstracts of the 13th Annual SCMR Scientific Sessions - 2010
Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/files/pdf/1532-429X-11-S1-infoThis abstract is available from: http://jcmr-online.com/content/12/S1/O54 © 2010 Morelos; licensee BioMed Central Ltd.
To determine the prevalence of heart involvement in a cohort of patients with SSc, to describe the patterns of heart involvement in these patients using cardiac MRI, and to correlate these data with disease subsets and target organ involvement.
than in lcSSc (2.3%; p = 0.05); 90% showed diastolic dysfunction. Ninety two percent of coronary angiotomographies were normal (mean Ca score 3.7); 26.5% of patients had abnormal EKGs (50% of dcSSc vs 5.6% of lcSSc, p = 0.006). Cardiac fibrosis was directly associated with cardiac microvascular damage (p = 0.03), lower LVEF (62 vs 55%, p = 0.002) and inversely associated with vascular (41 vs 59%, p = 0.03) and muscular involvement (26 vs 73%, p = 0.05). Microvascular damage was associated with higher thickness skin scores (18 vs 11 points, p = 0.03). There was no association of cardiac fibrosis with abnormal calcium score. There were no other associations with clinical or laboratory values.
Methods
Conclusion
We included SSc patients from the SSc cohort of our Institution. They underwent clinical evaluation, EKG, CPK, CPK-MB, CRP, ESR, specific SSc autoantibodies, coronary angiotomography (GE, 64 multidetectors) and cardiac MRI (1.5 T... GE, sequencies in T1 GRE Delay Enhancement to evaluate myocardial damage, resting and postadenosine myocardial perfusion - TIGRE-echoplanarimaging) was analyzed semiquantitatively with signal intensity curves.
Patients with systemic sclerosis show preserved systolic function, high frequency of cardiac fibrosis, diastolic dysfunction and subendocardic concentric perfusion defects, related to microvascular damage. Cardiac MRI is a sensitive, noninvasive, useful method to detect heart involvement in SSc.
Introduction Systemic sclerosis (SSc) is an autoinmune disease characterized by tissue fibrosis and microvascular damage. Heart involvement has been described in 37-80% of patients; prevalence rates vary depending on the diagnostic method and the type of patients included in the studies.
Purpose
Results We have included 43 SSc patients (24 patients with diffuse cutaneous SSc (dcSSc): 56% and 19 patients with limited cutaneous SSc (lcSSc): 44%; 42 of them were female); mean age 41 years, mean time of evolution: 10.2 years; mean LVEF
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