Cartilage Volume 2: Pathophysiology
In three Volumes this mini book series presents current knowledge and new perspectives on cartilage as a specialized yet versatile tissue. This second volume is dedicated to basic pathologies of the two most common osteoarticular diseases affecting large
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artilage Volume 2: Pathophysiology
Cartilage
Susanne Grässel • Attila Aszódi Editors
Cartilage Volume 2: Pathophysiology
Editors Susanne Grässel Orthopädische Klinik für die Universität Regensburg Universitätsklinikum Regensburg Regensburg Germany
Attila Aszódi Department of General, Trauma, and Reconstruction Surgery Ludwig-Maximilians-University Munich Germany
ISBN 978-3-319-45801-4 ISBN 978-3-319-45803-8 (eBook) DOI 10.1007/978-3-319-45803-8 Library of Congress Control Number: 2017931314 © Springer International Publishing Switzerland 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
Volume two of this book series comprised of three volumes is dedicated to provide an overview about the pathophysiology of cartilage, joint tissue, and intervertebral disks. The text is designed to be of use to multiple medical and basic science disciplines as orthopedics, rheumatology, and trauma surgery and all basic investigators working in the field of cartilage, joint, and intervertebral disk pathophysiology. This volume focuses on the major cartilage pathophysiologies which include osteoarthritis and rheumatoid arthritis, degeneration of intervertebral disks, and genetic skeletal diseases as cartilage collagenopathies and other hereditary chondrodysplasias resulting from mutations in structural cartilage proteins. Chapter 1 provides an overview about osteoarthritis (OA) which is the most common joint disorder and known as a leading cause of disability in the adult population. It is now appreciated that all components of the joint, including the cartilage, calcified cartilage, synovial joint lining, and periarticular bone, undergo pathological changes during the initiation and progression of OA. Some of these alterations can be attributed to direc
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