Cell Surface Receptors and the G Protein-Coupled Receptor Superfamily
Transduction of extracellular signals across the plasma membrane to the intracellular environment is achieved by the interaction of regulatory molecules with specific membrane-spanning cell surface receptors. Interaction of an appropriate activating ligan
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G PROTEIN-COUPLED RECEPTORS Tiina P. Iismaa, Ph.D. TrevorJ. Biden, Ph.D. John Shine, Ph.D. Garvan Institute of Medical Research St. Vincent's Hospital Sydney, Australia
SPRINGER-VERLAG BERLIN HEIDELBERG GMBH
MoLECULAR BIOLOGY INTELUGENCE UNIT G PROTEIN-COUPLED RECEPTORS R.G. LANDES COMPANY Austin, Texas, U.S.A. Submitted: October 1994 Published: January 1995
U.S. and Canada Copyright© 1995 R.G. Landes Company All rights reserved.
International Copyright© 1995 Springer-Verlag Berlin Heidelberg Softcover reprint of the hardcover lst edition 1995
All rights reserved. International ISBN 978-3-662-21932-4 While the authors, editors and publisher believe that drug selection and dosage and the specifications and usage of equipment and devices, as set forth in this book, are in accord with current recommendations and practice at the time of publication, they make no warranty, expressed or implied, with respect to material described in this book. In view of the ongoing research, equipment development, changes in governmental regulations and the rapid accumulation of information relating to the biomedical sciences, the reader is urged to carefully review and evaluate the information provided herein.
Library of Congress Cataloging-in-Publication Data
Iismaa, Tiina P. G protein-coupled receptors I Tiina P. Iismaa, Trevor]. Biden, John Shine. p. cm.-Molecular biology intelligence unit) Includes bibliographical references and index. ISBN 978-3-662-21932-4 ISBN 978-3-662-21930-0 (eBook) DOI 10.1007/978-3-662-21930-0
1. G proteins-Receptors. 2. Cell receptors. 3. Cellular signal transduction. I. Biden, Trevor]. II. Shine, John. III. Title. IV. Series. 94-38448 QP552. G16I35 1995 CIP 574.19'245--d.c20
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~====CONTENTS 1. Cell Surface Receptors and the G Protein-Coupled Receptor Superfamily ............................................................ 1 Cell Surface Receptors ................................................................. 1 Structural and Functional Features of G Protein-Coupled Receptors ........................................... 16 Molecular Cloning of G Protein-Co
