Changes in the Biorhythms of Biochemical Parameters in Animals with Modeled Acute Desynchronosis
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D BIOCHEMISTRY Changes in the Biorhythms of Biochemical Parameters in Animals with Modeled Acute Desynchronosis E. G. Batotsyrenova1,3, S. E. Bakulev2, T. G. Nevzorova2, M. B. Ivanov1, V. A. Kashuro1, E. A. Zolotoverkhaja1, T. A. Kostrova1, and A. V. Sharabanov1
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 170, No. 8, pp. 155-159, August, 2020 Original article submitted March 16, 2020 This article describes models for the study of acute desynchronosis: jetlag syndrome and acute desynchronosis under physical stress for possible pharmacological correction of these disorders. The cosinor analysis allowed assessing significance of changes in biological rhythms in 2 biological models: the jetlag-type diurnal rhythm shift model and the model with changed light mode. The revealed changes in the rhythms of biochemical parameters in the blood serum of animals with acute desynchronosis indicate significant changes in the intensity of carbohydrate-lipid metabolism, which affected the processes of cell bioenergetics. These changes are most pronounced in the group of animals that were kept under conditions of constant darkness, which can serve as a marker of the initial stage of pathological desynchronosis. The jetlag-type model can be used to evaluate the effectiveness of the pharmacological correction of physiological desynchronosis. The model with modified light regimen can be used for evaluation of the effectiveness of pharmacological correction of pathological desynchronosis. Key Words: desynchronosis modeling; jetlag; cosinor analysis; biorhythms
Biological rhythms control body functions from the cellular to the behavioral level. The leading role in the organization of biosystems is played by circadian rhythms. Biorhythm disturbances can be subdivided into acute and chronic desynchronosis. Acute desynchronosis is observed during transcontinental and trans-meridian flights. Jetlag is a syndrome that develops after sharp changes of time zones. Usually, the manifestations of the syndrome are observed in people who cross more than 3 time zones, which leads 1 Institute of Toxicology, Federal Medical-Biological Agency of Russia, St. Petersburg, Russia; 2P. F. Lesgaft National State University of Physical Education, Sport and Health, St. Petersburg, Russia; 3St. Petersburg State Pediatric Medical University, Ministry of Health of the Russian Federation, St. Petersburg, Russia. Address for correspondence: [email protected]. E. G. Batotsyrenova
to misalignment of internal rhythms and the day-night rhythm at the place of arrival [3]. Acute desynchronosis can transform into a chronic one, which will undoubtedly be an indispensable component of pathological conditions. Acute desynchronosis can transform into latent desynchronosis. The duration of acute desynchronosis depends on many factors and can last from 5 to 10-15 days. Violation of the rhythm of the system leads to their inconsistency and the development of desynchronosis manifesting in impairment of energy metabolism, immunity, and cognitive a
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