Chemical Constituents from the Whole Plant of Cuscuta reflexa
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ORIGINAL ARTICLE
Chemical Constituents from the Whole Plant of Cuscuta reflexa Tin Thu Thu Aung1,3 · Meng‑Yuan Xia1 · Pyae Phyo Hein1,3 · Rong Tang1 · Dong‑Dong Zhang1,4 · Jun Yang1,4 · Xue‑Fei Yang1,4 · Dong‑Bao Hu2 · Yue‑Hu Wang1,4 Received: 26 June 2020 / Accepted: 9 September 2020 / Published online: 21 September 2020 © The Author(s) 2020
Abstract Two new 2H-pyran-2-one glucosides, cuscutarosides A (1) and B (2), and one new steroidal glucoside, 7β-methoxy-βsitosterol 3-O-β-glucopyranoside (3), together with 12 known compounds (4–15) were isolated from the whole plant of Cuscuta reflexa (Convolvulaceae) collected from Myanmar. The chemical structures of these new compounds were elucidated based on extensive spectroscopic analysis. The antiobesity activity of these isolates was evaluated using porcine pancreatic lipase (PPL), and the antiplatelet aggregation activity was screened using rabbit platelets induced by thrombin, plateletactivating factor (PAF), arachidonate (AA), or collagen. 7β-Methoxy-β-sitosterol 3-O-β-glucopyranoside (3) showed weak PPL inhibitory activity. Cuscutaroside A (1), its acetylated derivative (1a), and scrophenoside B (8) showed weak inhibitory activity against rabbit platelet aggregation induced by collagen. Compound 1a also showed inhibitory activity against rabbit platelet aggregation induced by AA. Graphic Abstract
Keywords Cuscuta reflexa · Porcine pancreatic lipase · Platelet aggregation · 2H-pyran-2-one glucosides · Steroidal glucosides Tin Thu Thu Aung and Meng-Yuan Xia contributed equally to this work. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s13659-020-00265-x) contains supplementary material, which is available to authorized users. * Dong‑Bao Hu [email protected]
2
School of Chemical Biology and Environment, Yuxi Normal University, Yuxi 653100, People’s Republic of China
* Yue‑Hu Wang [email protected]
3
University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China
4
Southeast Asia Biodiversity Research Institute, Chinese Academy of Sciences, Yezin, Nay Pyi Taw 05282, Myanmar
1
Key Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People’s Republic of China
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T. T. T. Aung et al.
1 Introduction
2 Results and Discussion
Cuscuta reflexa Roxb. (Convolvulaceae), a twining parasitic plant, is distributed in China, Afghanistan, India, Indonesia, Malaysia, Myanmar, Nepal, Pakistan, Sri Lanka, and Thailand [1]. In Nujiang Prefecture, Yunnan Province, China, the Lisu people call it mu-gua-zhua and use its whole plant or seeds to treat soreness and weakness of the waist and knees, erectile dysfunction, spermatorrhea, diabetes, dizziness, hypopsia, and threatened abortion [2]. Named shwe-new or shwe-nwe-pin (Hsay) in Myanmar, the whole plant of C. reflexa is used to treat inflammation, irregularities of the blood, and other
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