Climate and air pollution exposure are associated with thyroid function parameters: a retrospective cross-sectional stud
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ORIGINAL ARTICLE
Climate and air pollution exposure are associated with thyroid function parameters: a retrospective cross‑sectional study Y. Zeng1 · H. He1 · X. Wang1 · M. Zhang1 · Z. An2 Received: 19 July 2020 / Accepted: 26 October 2020 © Italian Society of Endocrinology (SIE) 2020
Abstract Objectives There are still controversies about the impact of climatic and environmental factors on thyroid function parameters in healthy populations. We investigated the relationships between climate, air pollution exposure, and thyroid function fluctuations. Methods We retrospectively reviewed 327,913 individuals attending routine health checks from December 2013 to December 2018. We analyzed the associations between thyroid function and climatic factors using Spearman’s correlation analysis. We explored the relationships between thyroid function and air pollution exposure using multiple linear regression analysis, after adjusting for age, sex, season, and outdoor temperature. We also performed subgroup analyses by age and sex and sensitivity analyses of different anti-thyroid peroxidase antibody status. Results Thyroid-stimulating hormone (TSH) and free triiodothyronine (FT3) were negatively associated with outdoor temperature (r = − 0.66, P
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