Clinicopathological significance of cancer stem cells marked by CD133 and KAI1/CD82 expression in laryngeal squamous cel
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RESEARCH
WORLD JOURNAL OF SURGICAL ONCOLOGY
Open Access
Clinicopathological significance of cancer stem cells marked by CD133 and KAI1/CD82 expression in laryngeal squamous cell carcinoma Lan Yu1†, Lei Zhou1†, Shiwu Wu1*†, Xiaomeng Gong1, Zhenzhong Feng1, Li Ma1, Bo Zhu1, Nan Yao1, Danna Wang1 and Huiming Dong2
Abstract Background: Presently, CD133 is one of the hottest markers to characterize cancer stem cells and KAI1/CD82 is reported as an important marker for the metastasis and prognosis of many cancers. The purpose of our study is to explore the relationship between cancer stem cells (CSCs) marked by CD133 and KAI1/CD82 expression and the clinicopathological characteristics of patients with laryngeal squamous cell carcinoma (LSCC). Methods: Immunohistochemical analysis was used to detect the expression of CD133 and KAI1/CD82 in 83 archival surgical specimens of human LSCC and 83 cases of normal laryngeal tissues. Results: In LSCC, positive rates of 49.4% and 41.0% were obtained for CD133 and KAI1/CD82, respectively. The expression of CD133 in LSCC tissues was significantly higher than that in normal tissues (P < 0.001), and the expression of CD133 was positively associated with pTNM stage (P = 0.005), pathological grade (P = 0.001), and lymph node metastasis (P < 0.001). The reduced expression of KAI1/CD82 was present in LSCC tissues. The positive rate of KAI1/CD82 expression was negatively correlated with pTNM stage (P = 0.014), pathological grade (P < 0.001), and lymph node metastasis (P = 0.007). A correlation analysis showed that there was a negative relationship between the expression of CD133 and KAI1/CD82 protein in LSCC tissues (P < 0.001). By Kaplan-Meier analysis, the expression of CD133 was negatively correlated with overall survival (OS) (log-rank = 40.949, P < 0.001) and diseasefree survival (DFS) (log-rank = 39.307, P < 0.001) time of LSCC. The expression of KAI1/CD82 was positively correlated with OS (log-rank = 40.279, P < 0.001) and DFS (log-rank = 39.271, P < 0.001) time of LSCC. Cox regression analysis: the expression of CD133 and KAI1/CD82, and pTNM stages were independent prognostic factors of LSCC (P < 0.05). Conclusions: Thus the detection of CD133 and KAI1/CD82 proteins may be used as a potential indicator of LSCC prognosis.
Background In the United States, laryngeal carcinoma accounted for approximately 0.82% of new cancer diagnoses and 0.40% of all cancer deaths in 2012 [1]. The major pathological type of laryngeal cancers is squamous cell carcinoma, accounting for 99% of laryngeal malignant tumors. Although rapid progress has recently been made in treatment, the prognosis for patients with laryngeal squamous cell * Correspondence: [email protected] † Equal contributors 1 Department of Pathology, the First Hospital Affiliated to Bengbu Medical College, Bengbu Medical College, 800 Zhihuai Ave, Longzihu, Bengbu, Anhui, China Full list of author information is available at the end of the article
carcinoma (LSCC) remains unsatisfactory. A major problem in finding treatments is t
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