Colon carcinoma treated with oxaliplatin and capecitabine in a 12-year-old child
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Colon carcinoma treated with oxaliplatin and capecitabine in a 12-year-old child Dong-Lai Hu, Xiao-Dong Guo, Zhi-Nan Sun, Yan-Min Zhao Jinhua, China
Case report
Background: XELOX (oxaliplatin 130mg/m 2 iv, capecitabine 1000mg/m 2 bid oral d1-14, q3w) chemotherapy has never been used in children. In this report, we present a case of a 12-year-old girl with colon adenocarcinoma, treated with surgery and XELOX chemotherapy. Methods: On admission, the girl complained of abdominal pain and intestinal obstruction. Physical examination revealed a distended abdomen with tenderness on the left upper quadrant. Barium enema revealed a stenotic lesion at the distal end of the transverse colon, and abdominal computed tomography showed acute obstruction and a colonic mass. Laparotomy was performed after the failure of conservative treatment. R e s u l t s : T h e m a s s w a s o r i g i n a t e d f ro m t h e transverse colon. Frozen sections of the specimens revealed an adenocarcinoma. Transverse colectomy was performed and regional lymph nodes were removed. Pathological examination confirmed that the mass was a poorly differentiated adenocarcinoma, and XELOX chemotherapy was used. No evidence of recurrent or metastatic tumor was found after 18 months. Conclusion: Although complete resection is the most effective treatment, XELOX chemotherapy is beneficial to the improvement of clinical outcome of patients with colon adenocarcinoma. World J Pediatr 2014;10(1):86-88 Key words: chemotherapy; colon adenocarcinoma; XELOX regimen
Author Affiliations: Department of Pediatric Surgery, Jinhua Hospital of Zhejiang University, Jinhua Municipal Central Hospital, Jinhua 321000, China (Hu DL, Guo XD, Sun ZN, Zhao YM) Corresponding Author: Xiao-Dong Guo, MD, Department of Pediatric Surgery, Jinhua Hospital of Zhejiang University, Jinhua Municipal Central Hospital, Jinhua 321000, China (Tel: 86-579-82552985; Email: [email protected]) doi: 10.1007/s12519-014-0459-z ©Children's Hospital, Zhejiang University School of Medicine, China and Springer-Verlag Berlin Heidelberg 2014. All rights reserved.
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Introduction
C
olorectal cancer (CRC) is an extremely rare tumor in children. Because of this rarity, the role of adjuvant chemotherapy has not been adequately evaluated in children with regard to safety profile and treatment response after application of novel agents.[1] This report presents a case of a 12-year-old girl with CRC treated with XELOX, i.e. combination of oxaliplatin and capecitabine. This case demonstrates that adjuvant chemotherapy helps to improve prognosis of CRC patients, with a good safety profile without significant adverse effects.[2,3]
Case report A 12-year-old girl with complaints of abdominal pain and intestinal obstruction for three days was brought to our department. Clinical examination revealed no palpable mass but pain and tenderness on the left upper quadrant. Hematological tests including biochemistry and serum carcinoembryonic antigen (CEA) showed nothing abnormal. Barium enema revealed a stenotic lesion at the
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