Cross-segment spinal plasma cell granuloma:a case report
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CASE REPORT
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Cross-segment spinal plasma cell granuloma:a case report Renqin Lin1†, Shenglin Wang1†, Jianhua Lin1, Zhenzhen Zhang2 and Xuanwei Chen1*
Abstract Background: Plasma cell granuloma (PCG) is a rare non-neoplastic entity, with the precise etiology remaining unclear. Vertebra-affected spinal PCG has not been reported yet. This report presented a case with cross-segment spinal PCG in thoracolumbar region. Case presentation: A 32-year-old male patient presented to the authors’ hospital since his health check-up results showed osteolytic lesions in the thoracolumbar spine. He felt asymptomatic throughout the course. Radiological examination revealed destructive changes at T12 and L1 vertebrae. Whereas laboratory examination excluded malignant tumor. The results of routine incisional biopsy remained inconclusive, thereby necessitating complete excision of the lesions. Finally, the infiltration of plasma cells observed by pathological examination of the surgical specimen confirmed the diagnosis of PCG. Conclusions: To the authors’ knowledge, this was the first case of cross-segment spinal PCG with osteolytic property. The possibility of PCG should be considered for the diagnosis and differential diagnosis of an osteolytic lesion in the spine. Since the etiology of PCG is unknown, the disorder was confirmed based on excluded diagnosis. Surgical resection is recommended both for the definite diagnosis and treatment of spinal PCG. Keywords: Plasma cell granuloma, Thoracolumbar spine, Surgery, Case report
Background Plasma cell granuloma (PCG), firstly mentioned by Bahadori and Liebow, is a pseudotumor-like condition characterized by the polyclonal proliferation of plasma cells. The etiopathogenesis of PCG is still unknown. Although PCG is regarded as a generally benign and nonrecurring lesion, the outcome of those with local aggressiveness or recurrence may become complicated. PCG is commonly seen in lung and occasionally seen in esophagus, mouth, stomach, thyroid gland, intestine, kidney, lymph node, and skin. Additionally, PCG was ever found in jaw and temporal bone. However, vertebra involved PCG has not been reported yet. We here * Correspondence: [email protected] † Renqin Lin and Shenglin Wang contributed equally to this work. 1 Department of Orthopedic Surgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, P.R. China Full list of author information is available at the end of the article
reported the first case of cross-segment PCG occurred in the thoracolumbar spine. This report was approved by the Ethics Committee of our hospital. Informed consent was obtained from the patient concerning the data submitted for publication.
Case presentation A 32-year-old man presented to the local hospital for health check-up and the computed tomography (CT) scan pitched upon osteolytic lesions in his thoracolumbar spine. Three days later, he was referred to our hospital for further management. Throughout the course, he had no pain or fever, with negative neuroradiolo
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