Effects of Probiotic Yogurt on Serum Omentin-1, Adropin, and Nesfatin-1 Concentrations in Overweight and Obese Participa
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Effects of Probiotic Yogurt on Serum Omentin-1, Adropin, and Nesfatin-1 Concentrations in Overweight and Obese Participants Under Low-Calorie Diet Mitra Zarrati 1 & Mahsa Raji Lahiji 1 & Eisa Salehi 2 & Bahareh Yazdani 3 & Elham Razmpoosh 4,5 & Raheleh Shokouhi Shoormasti 6 & Farzad Shidfar 1
# Springer Science+Business Media, LLC, part of Springer Nature 2018
Abstract Data on the effects of probiotics on adipokines such as omentin-1, nesfatin-1, and adropin are limited. The aim of this study was to evaluate the effects of probiotic yogurt along with a low-calorie diet (LCD) on serum omentin-1, adropin, and nesfatin-1 concentrations in obese and overweight individuals. Sixty obese or overweight individuals aged 20–50 years old were involved in this randomized double-blind placebo-controlled clinical trial. Participants were randomly allocated into two groups to consume either probiotic yogurt containing Lactobacillus acidophilus La5, Bifidobacterium BB12, and Lactobacillus casei DN001 (108 CFU/g each) (n = 30) or regular yogurt (n = 30) along with a LCD in both groups for 8 weeks. Fasting blood samples were taken at baseline and after the 8-week intervention to determine related variables. A significant decrease in body fat percentage was observed in the probiotic group compared with the regular group after 8 weeks (− 1.51 ± 069 vs − 0.88 ± 0.68%, P = 0.002). After the 8-week intervention, a significant difference in serum adropin concentration (6.04 ± 24.46 vs − 8.16 ± 24.66 pg/ml, P = 0.03 and serum omentin-1 concentration (0.09 ± 1.51 vs − 1.5 ± 1.8 ng/ml, P = 0.003) was observed between two groups. We did not observe any significant changes in nesfatin-1 and other anthropometric measures. Overall, probiotic yogurt for 8 weeks among overweight or obese individuals along with LCD had beneficial effects on body fat percentage, serum omentin-1, and adropin concentration, but it did not have any effect on nesfatin-1 level. Keywords Weight reduction . Probiotic . Omentin-1 . Adropin . Nesfatin-1
Introduction Obesity is increasingly recognized as a serious worldwide public health concern. This problem is a chronic condition of low* Farzad Shidfar [email protected] 1
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
2
Immunology Department, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
3
Department of Microbiology, School of Biology Sciences, Islamic Azad University, Tehran, Iran
4
Department of Nutrition, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
5
Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
6
Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
grade inflammation [1]. However, in recent years, it has become increasingly clear that adipose tissue is a dynamic endocrine organ that releases more than 600 bioactive factors known as adipokines [2]. Adipokines play critical roles in
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