Efficacy and Safety of Intralesional Triamcinolone Versus Combination of Triamcinolone with 5-Fluorouracil in the Treatm
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REVIEW
SPECIAL TOPICS
Efficacy and Safety of Intralesional Triamcinolone Versus Combination of Triamcinolone with 5-Fluorouracil in the Treatment of Keloids and Hypertrophic Scars: A Systematic Review and Meta-analysis Zheng-Ying Jiang1 • Xin-Cheng Liao1 • Ming-Zhuo Liu1 • Zhong-Hua Fu1 Ding-Hong Min1 • Xiao-Ting Yu1 • Guang-Hua Guo1
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Received: 19 February 2020 / Accepted: 9 April 2020 Ó Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery 2020
Abstract Background Although keloids and hypertrophic scars are common benign hyperproliferative growths of dermal fibroblasts, the clinical problems including physical and psychological problems are significant and impairing, with few proven treatments. Intralesional triamcinolone acetonide (TAC) and combination of TAC with 5-fluorouracil (5-FU) are widely used to treat keloids and hypertrophic scars, but their efficacy and safety remain controversial. Methods We systematically searched MEDLINE, EMBASE, Cochrane Library, and CNKI for relevant trials. Results The mean scar height and the erythema score in the TAC ? 5-FU group were lower than those in the TAC group after treatment (P \ 0.05). The effectiveness based on observer assessment after treatment in the TAC ? 5-FU group was superior than that in the TAC group (P \ 0.05);
& Guang-Hua Guo [email protected] Zheng-Ying Jiang [email protected] Xin-Cheng Liao [email protected]
further, the subgroup analysis showed the TAC ? 5-FU group was also superior than the TAC group in the treatment of hypertrophic scars (P = 0.01), and there were no significant differences in the treatment of keloid (P = 0.12). The effectiveness based on patient selfassessment after treatment in the TAC ? 5-FU group was also superior than the TAC group (P \ 0.05). The overall complication rate in the TAC ? 5-FU group was lower than the TAC group (P \ 0.05). Conclusions Combination of TAC with 5-FU is more effective and safer than TAC alone therapy in the treatment of keloids and hypertrophic scars. Data on keloids alone or hypertrophic scars alone are, however, limited. A better understanding of effective after intralesional combination of TAC with 5-FU in the treatment of keloids alone or hypertrophic scars alone is imperative. Level of Evidence IV This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266. Keywords 5-Fluorouracil Triamcinolone acetonide Keloids Hypertrophic scars Meta-analysis
Ming-Zhuo Liu [email protected] Zhong-Hua Fu [email protected]
Introduction
Ding-Hong Min [email protected]
Keloids and hypertrophic scars are common benign disorders that develop as a result of hyperproliferative growth of dermal fibroblasts after trauma. They are also characterised by derangements of the wound healing process and excess accumulation of collagen in the wound [1, 2]. However, keloid
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