Evaluation of immunophenotypic markers and clinico-hematological profile in chronic lymphocytic leukemia: implications f
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BMC Research Notes Open Access
RESEARCH NOTE
Evaluation of immunophenotypic markers and clinico‑hematological profile in chronic lymphocytic leukemia: implications for prognosis Marziye Bagheri1,2, Tina Vosoughi1, Mehran Hosseinzadeh1 and Najmaldin Saki1*
Abstract Objective: Chronic lymphocytic leukemia (CLL) is an adult leukemia presented with clonal accumulation of lymphocytes. Immunophenotypic changes can be effective in predicting clinical course, the survival of patients, and determining first-line treatment. This is a study of the association between immunophenotypic markers with complete blood cell count (CBC) values and clinical parameters. Results: Peripheral blood samples were collected from 35 newly diagnosed CLL patients. The expression of immunophenotypic markers and CBC were evaluated. Platelet counts and hemoglobin concentration had a significant, inverse association with Rai staging, modified Rai staging, Binet staging systems (all p
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