Exparel for Postoperative Pain Management: a Comprehensive Review
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OTHER PAIN (N VADIVELU AND AD KAYE, SECTION EDITORS)
Exparel for Postoperative Pain Management: a Comprehensive Review Alan David Kaye 1 & Cassandra Armstead-Williams 2 & Farees Hyatali 3 & Katherine S. Cox 4 & Rachel J. Kaye 5 & Lauren K. Eng 6 & Muhammad A. Farooq Anwar 7 & Perene V. Patel 8 & Shilpa Patil 3 & Elyse M. Cornett 3 Accepted: 17 September 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose of Review Multimodal pain management is the most effective way to treat postsurgical pain. However, the use of opioids for acute pain management has unfortunately been a significant contributor to the current opioid epidemic. The use of opioids should be limited and only considered a “rescue” pain medication after other modalities of pain management have been utilized. Recent Findings It may be difficult to curtail the use of opioids in the treatment of chronic pain; however, in the postsurgical setting, there is compelling evidence that an opioid-centric analgesic approach is not necessary for good patient outcomes and healthcare cost benefits. Opioid-related adverse effects are the leading cause of preventable harm in the hospital setting. After the realization in recent years of the many harmful effects of opioids, alternative regimens including the use of multimodal analgesia have become a standard practice in acute pain management. Exparel, a long-lasting liposomal bupivacaine local anesthetic agent, has many significant benefits in the management of postoperative pain. Summary Overall, the literature suggests that Exparel may be a significant component for postoperative multimodal pain control owing to its efficacy and long duration of action. Keywords Exparel . Postoperative pain . Pain management . Opioid-free . Non-opioid
This article is part of the Topical Collection on Other Pain * Elyse M. Cornett [email protected]
Shilpa Patil [email protected]
Alan David Kaye [email protected]; [email protected]
1
Cassandra Armstead-Williams [email protected]
Department Pharmacology, Toxicology, and Neuroscience, LSU Health Shreveport, Shreveport, LA, USA
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Department of Anesthesia, Department of Anesthesiology, LSU Health Sciences Center, Room 656, 1542 Tulane Ave., New Orleans, LA 70112, USA
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Department of Anesthesiology, LSU Health Shreveport, 1501 Kings Highway, Shreveport, LA 71103, USA
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Department of Anesthesiology, Tulane University Medical Center, 1415 Tulane Ave, New Orleans, LA 70112, USA
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Medical University of South Carolina, Charleston, SC 29425, USA
6
Tulane School of Medicine, New Orleans, LA 70112, USA
Muhammad A. Farooq Anwar [email protected]
7
Department of Anesthesiology, 1415 Tulane Ave, New Orleans, LA 70112, USA
Perene V. Patel [email protected]
8
Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, 5777 East Mayo Blvd, Phoenix, AZ 85054, USA
Farees Hyatali [email protected] Katherine S. Cox [email protected] Rachel J. Kaye [email protected] Lauren K. Eng [email protected]
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