Fibrogenesis: Cellular and Molecular Basis

Fibrogenesis: Cellular and Molecular Basis is the first volume to provide a synopsis of the rapid progress that has been documented in fibrogenesis over last couple of years, which significantly enhanced our understanding of the pathomechanisms of fibroti

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Fibrogenesis; Cellular and Molecular Basis Mohammed S. Razzaque, M.D., Ph.D. Department of Oral and Developmental Biology Harvard School of Dental Medicine The Forsyth Institute Boston, Massachusetts, U.S.A.

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FiBROGENESIS: CELLULAR AND MOLECULAR BASIS Medical Intelligence U n i t Eurekah.com / Landes Bioscience Kluwer Academic / Plenum Publishers

Copyright ©2005 Eurekah.com and Kluwer Academic / Plenum Publishers All rights reserved. N o part of this book may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Printed in the U.S.A. Kluwer Academic / Plenum PubUshers, 233 Spring Street, New York, New York, U.S.A. 10013 http://www.wkap.nl Please address all inquiries to the Publishers: Landes Bioscience / Eurekah.com, 810 South Church Street, Georgetown, Texas, U.S.A. 78626 Phone: 512/ 863 7762; FAX: 512/ 863 0081 http://www.eurekah.com http://www.landesbioscience.com ISBN: 0-306-47861-7 Selective Sweep edited by Dmitry Nurminsky, Landes / Kluwer dual imprint / Landes series: Molecular Biology Intelligence Unit While the authors, editors and publisher believe that drug selection and dosage and the specifications and usage of equipment and devices, as set forth in this book, are in accord with current recommendations and practice at the time of publication, they make no warranty, expressed or implied, with respect to material described in this book. In view of the ongoing research, equipment development, changes in govemmental regulations and the rapid accumulation of information relating to the biomedical sciences, the reader is urged to carefully review and evaluate the information provided herein. Library o f Congress C a t a l o g i n g - i n - P u b l i c a t i o n D a t a Fibrogenesis : cellular and molecular basis / [edited by] Mohammed S. Razzaque. p . ; cm. — (Medical intelligence unit) Includes bibliographical references and index. ISBN 0-306-47861-7 1. Fibrosis. I. Razzaque, Mohammed S. II. Series: Medical intelligence unit (Unnumbered : 2003) [DNLM: 1. Fibrosis-pathology. 2. Molecular Biology. Q Z 150 F443 2005] RB150.F52F53 2005 6l6.77~dc22 2004023420

To my father, N.M A. Razzaque Mojumder, who taught me how to hold a pen, how to write and, most importantly, nudged me to believe in my dreams. Although he passed away over twenty years ago, his teaching of doing the right things in life over the easy things is ever enduring for me.

CONTENTS Preface 1.

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Tissue Scarring: Lessons from Wound Healing Mohammed S. Razzaque, Moussa El-Hallak, Abdullah Azouz and Takashi Taguchi Wound Healing Fetal Wound Healing Tissue Scarring Pathological Significance of Renal Expression of Proinflammatory Molecules Takashi Wada, Mohammed S. Razzaquey Kouji Matstishimay Takashi Taguchi and Hitoshi Yokoyama Particip