Fluoxetine
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Acquired platelet qualitative disorders: case report A 14-year-old boy developed acquired platelet qualitative disorder during treatment with fluoxetine for impulsive and aggressive behaviour. The boy presented with spontaneous fresh bleeding from mouth 10–12 times/day. Associated cough or vomiting was not noted. As he was adopted, family history was not available. Examinations showed no obvious signs of oral lesion, and negative for hepatosplenomegaly and lymphadenopathy. Systemic examinations, liver function tests and renal function tests also showed normal results. Haematological examinations showed normal platelet count, coagulation profile and peripheral smear. Bronchoscopy and upper GI endoscopy ruled out respiratory and gastrointestinal causes. After all possible aetiologies were ruled out, careful repeat anamnesis revealed that he had been receiving treatment with fluoxetine for impulsive and aggressive behaviour [route and dosage not stated]. Subsequent platelet aggregation tests showed reduced response to adenosine diphosphate and epinephrine. Consequently, fluoxetine induced development of acquired platelet qualitative disorders was considered [duration of treatment to reaction onset not stated]. Hence, the boy’s fluoxetine therapy was stopped. He also underwent single donor platelet transfusions. The frequency of bleeding decreased and eventually stopped in one week after treatment discontinuation. During follow-up examination after 3 months, episodes of bleeding were not noted. Chatterjee G, et al. Fluoxetine induced bleeding in a pediatric case: A case report. Indian Journal of Hematology and Blood Transfusion 35 (Suppl.): S66 abstr. 19., No. 1, 26 803502832 Oct 2019. Available from: URL: http://doi.org/10.1007/s12288-019-01207-5 [abstract]
0114-9954/20/1823-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved
Reactions 26 Sep 2020 No. 1823
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