From Local Invasion to Metastatic Cancer Involvement of Distant Site

In human solid tumors, nodal status is the most important prognostic indicator for patient outcome. Recent developments in the sentinel lymph node concept have resulted in new procedures to define the first draining node as the primary gateway throug

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From Local Invasion to Metastatic Cancer

Involvement of Distant Sites Through the Lymphovascular System

FROM LOCAL INVASION TO METASTATIC CANCER

CURRENT CLINICAL ONCOLOGY Maurie Markman, MD, SERIES EDITOR From Local Invasion to Metastatic Cancer: Involvement of Distant Sites Through the Lymphovascular System, edited by STANLEY P.L. LEONG, 2009 Integrative Oncology: Incorporating Complementary Medicine into Conventional Cancer Care, edited by LORENZO COHEN AND MAURIE MARKMAN, 2008 Prostate Cancer: Signaling Networks, Genetics, and New Treatment Strategies,, edited by RICHARD G. PESTELL AND MARJA T. NEVALAINEN, 2008 Intraperitoneal Cancer Therapy, edited by WILLIAM C. HELM AND ROBERT EDWARDS, 2007 Molecular Pathology of Gynecologic Cancer, edited by ANTONIO GIORDANO, ALESSANDRO BOVICELLI, AND ROBERT KURMAN, 2007 Colorectal Cancer: Evidence-Based Chemotherapy Strategies, edited by LEONARD B. SALTZ, 2007 High-Grade Gliomas: Diagnosis and Treatment, edited by GENE H. BARNETT, 2006 Cancer in the Spine: Comprehensive Care, edited by ROBERT F. MCLAIN, KAI-UWE LEWANDROWSKI, MAURIE MARKMAN, RONALD M. BUKOWSKI, ROGER MACKLIS, AND EDWARD C. BENZEL, 2006 Squamous Cell Head and Neck Cancer, edited by DAVID J. ADELSTEIN, 2005 Hepatocellular Cancer: Diagnosis and Treatment, edited by BRIAN I. CARR, 2005 Biology and Management of Multiple Myeloma, edited by JAMES R. BERENSON, 2004 Cancer Immunotherapy at the Crossroads: How Tumors Evade Immunity and What Can Be Done, edited by JAMES H. FINKE AND RONALD M. BUKOWSKI, 2004 Treatment of Acute Leukemias: New Directions for Clinical Research, edited by CHING-HON PUI, 2003 Allogeneic Stem Cell Transplantation: Clinical Research and Practice, edited by MARY J. LAUGHLIN AND HILLARD M. LAZARUS, 2003 Chronic Leukemias and Lymphomas: Biology, Pathophysiology, and Clinical Management, edited by GARY J. SCHILLER, 2003 Colorectal Cancer: Multimodality Management, edited by LEONARD SALTZ, 2002 Breast Cancer: A Guide to Detection and Multidisciplinary Therapy, edited by MICHAEL H. TOROSIAN, 2002 Melanoma: Biologically Targeted Therapeutics, edited by ERNEST C. BORDEN, 2002

FROM LOCAL INVASION TO M ETASTATIC C ANCER Involvement of Distant Sites Through the Lymphovascular System

Edited by

STANLEY P.L. LEONG, MD University of California, CA, USA

Stanley P.L. Leong Division of Surgical Oncology University of California San Francisco, CA, USA [email protected] Series Editor Maurie Markman Anderson Cancer Center University of Texas Houston, TX

ISBN 978-1-60327-086-1 DOI 10.1007/978-1-60327-087-8

e-ISBN 978-1-60327-087-8

Library of Congress Control Number: 2008938536 #Humana Press, a part of Springer ScienceþBusiness Media, LLC 2009 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer ScienceþBusiness Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information sto