Frontiers in Modeling and Control of Breathing Integration at Molecu

The field of neural control of breathing has advanced rapidly in the past two decades, with the emergence of many new and promising research directions of increasing sophistication. The complexity and diversity of the current methodologies signify its rem

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FRONTIERS IN MODELING AND CONTROL OF BREATHING INTEGRATION AT MOLECULAR, CELLULAR, AND SYSTEMS LEVELS Edited by

Chi-Sang Poon Massachusetts Institute 01 Technology Cambridge, Massachusetts

and

Homayoun Kazemi Massachusetts General Hospital and Harvard Medical School Boston, Massachusetts

Springer-Science+Business Media, LLC

Library of Congress Cataloging-in-Publication Data Frontiers in modeling and control of breatbing: integration at molecular, eellular, and systems levelsledited by Chi-Sang Poon and Homayoun Kazemi. p. em. - (Advanees in experimental medieine and biology; v. 499) "Tbe VIII Oxford Conference eonvened on October 11-15, 2000 at ... North Falmouth on Cape Cod in Massaehusetts, USA" -Pref. Includes bibliographie al references and index. ISBN 978-1-4613-5522-9 ISBN 978-1-4615-1375-9 (eBook) DOI 10.1007/978-1-4615-1375-9 1. Respiration-Regulation-Congresses. I. Poon, Chi-Sang, 1952- 11. Kazemi, Homayoun, 1934- III. Oxford Conferenee (8th: 2000: North Falmouth, Mass.) IV. Series. QP123 .F766 2001 612.2-de21 2001038337

Proceedings of the VIII Oxford Conferenee, held October 11-15, 2000, in North Falmouth, Massaehusetts. ISBN 978-1-4613-5522-9 ©2001 Springer Science+Business Media New York Originally published by Kluwer Academic/Plenum Publishers, New York in 2001 Softcover reprint of the hardcover 1st edition 2001 10 9

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A c.I.P. reeord for tbis book is available from the Library of Congress All rights reserved No part of tbis book may be reprodueed, stored in a retrieval system, or transmitted in any form or by any means, electronie, mechanical, photoeopying, mierofilming, recording, or otherwise, without written permission from the Publisher

Conference Proceedings

Integration at Molecular, Cellular, and Systems Levels October 11 -15,2000 N. Falmouth (Cape Cod), Massachusetts, USA

Conference Co-Chairs:

International Program Committee M. Aoki (Japan) E.N. Bruce (USA) J. Champagnat (France) J. Duffin (Canada) A.Guz (UK) M.C.K. Khoo (USA) J. Lipski (New Zealand) E.E. Nattie (USA) N. Prabhakar (USA) J.E. Remmers (Canada) D.W. Richter (Germany) G. Song (China) S.A. Ward (UK)

Chi-Sang Poon, (Cambridge, MA ) Homayoun Kazemi, (Boston, MA) International Organizing Committee G. Benchetrit (France) Y. Honda (Japan) R.L. Hughson (Canada) c.-S. Poon (USA) P.A. Robbins (UK) J.W. Severinghaus (USA) S.A. Ward (UK) B.J. Whipp (UK) Local Organizing Committee S.A. Shea (Boston, MA) M. Siniaia (Cambridge, MA) D. Systrom (Boston, MA) D. Ward (Rochester, NY)

The Organizing Committee gratefully acknowledges support from the following groups:

Sponsored by

The American Physiological Society The Physiological Society (UK) The Whitaker Foundation Respiration Physiology GlaxoSmithKline Inc. Harvard Apparatus, Inc.

Endorsed by

The American Thoracic Society

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PREFACE

Over the past two decades the international Oxford