Group B Streptococcus causes severe sepsis in term neonates: 8 years experience of a major Chinese neonatal unit
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Group B Streptococcus causes severe sepsis in term neonates: 8 years experience of a major Chinese neonatal unit Ying Dong, Si-Yuan Jiang, Qi Zhou, Yun Cao Shanghai, China
Methods: A retrospective case series study was performed at a high-capacity neonatal unit in Shanghai, China from January 2008 to December 2015. Clinical characteristics of neonates with culture-proven GBS sepsis and antibiotic susceptibility of isolated strains were analyzed. Results: Forty-three term neonates were included during the study period. The majority (74.4%) had early-onset sepsis with symptoms of respiratory distress. Meningitis was significantly more common in lateonset sepsis than in early-onset sepsis (81.5% vs. 18.8%, P38.0°C 9 (56.3) 16 (59.3) 0.847 Jaundice 8 (50.0) 15 (55.6) 0.761 Poor feeding 10 (62.5) 9 (33.3) 0.111 Lethargy 5 (31.3) 9 (33.3) 0.888 Poor perfusion 8 (50.0) 1 (3.7) 0.001 Seizure 3 (18.8) 2 (7.4) 0.344 Blood gas within 24 h of onset of symptoms, n (%) Number of samples 13 (81.3) 12 (44.4) pH, mean±SD 7.26±0.12 7.39±0.05 0.006 Lactate (mmol/L), median 10.8 (4.6-21.0) 6.3 (1.5-10.4) 0.119 (range) Peripheral blood test within 24 h of presentation, n (%) Number of samples 16 (100) 21 (77.8) WBC >20×103/μL 3 (18.8) 6 (28.6) 0.702 WBC
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