Human Fungal Pathogen Identification Methods and Protocols
This detailed volume presents timely and authoritative content offering a comprehensive overview of the current state of the art in fungal diagnostics. Moreover, it addresses on-going developments expected to provide a basis for targeted treatment strateg
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Thomas Lion Editor
Human Fungal Pathogen Identification Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Human Fungal Pathogen Identification Methods and Protocols
Edited by
Thomas Lion Children’s Cancer Research Institute (CCRI), St.Anna Kinderkrebsforschung, Vienna, Austria; LabDia Labordiagnostik GmbH, Vienna, Austria; Department of Pediatrics, Medical University of Vienna, Vienna, Austria
Editor Thomas Lion Children’s Cancer Research Institute (CCRI) St.Anna Kinderkrebsforschung Vienna, Austria LabDia Labordiagnostik GmbH Vienna, Austria Department of Pediatrics Medical University of Vienna Vienna, Austria
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-6513-7 ISBN 978-1-4939-6515-1 (eBook) DOI 10.1007/978-1-4939-6515-1 Library of Congress Control Number: 2016948722 © Springer Science+Business Media New York 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC New York The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A
Preface Fungal infections constitute an ever-growing healthcare problem worldwide. Invasive fungal disease (IFD) is a leading cause of morbidity and mortality in severely immunocompromised individuals, including a variety of critically ill patients. High-risk conditions for IFD include hematologic malignancies, hematopoietic stem cell or solid organ transplantations, primary or acquired immunodeficiencies such as AIDS, long-term treatment at intensive care units, preterm birth, long-term immunosuppressive therapy, broad-spectrum antibiotic therapy, and long presence of central indwelling catheters. Despite the availability of a number of pote
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